Issue 22, 2017

Synthesis of enaminones via copper-catalyzed decarboxylative coupling reaction under redox-neutral conditions

Abstract

A novel copper-catalyzed C(sp3)–H oxidative functionalization of aromatic oxime acetates with α-oxocarboxylic acids was reported. This process involved N–O/C–C bond cleavages and C–C bond formations to furnish substituted enaminones under redox-neutral conditions. The oxime acetates served as both reactants and internal oxidants. Furthermore, this transformation also features good functional group tolerance and needs no ligands or additional bases.

Graphical abstract: Synthesis of enaminones via copper-catalyzed decarboxylative coupling reaction under redox-neutral conditions

Supplementary files

Article information

Article type
Communication
Submitted
11 jan 2017
Accepted
21 fev 2017
First published
21 fev 2017

Chem. Commun., 2017,53, 3228-3231

Synthesis of enaminones via copper-catalyzed decarboxylative coupling reaction under redox-neutral conditions

Z. Zhu, X. Tang, J. Li, X. Li, W. Wu, G. Deng and H. Jiang, Chem. Commun., 2017, 53, 3228 DOI: 10.1039/C7CC00260B

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