Issue 108, 2016

Remote stereocontrolled asymmetric 1,6-addition/1,4-addition cascade reactions between cyclic dienones and 2-indolinethiones

Abstract

Highly enantioselective 1,6-addition/1,4-addition cascade reactions between cyclic dienones and 2-indolnethiones have been realized by employing a cinchona-based primary amine catalyst. This method displays a broad substrate scope and provides a simple and highly effective way to achieve the chiral spiro[thiopyranoindole-cyclohexanone] scaffold.

Graphical abstract: Remote stereocontrolled asymmetric 1,6-addition/1,4-addition cascade reactions between cyclic dienones and 2-indolinethiones

Supplementary files

Article information

Article type
Communication
Submitted
06 ago 2016
Accepted
31 out 2016
First published
31 out 2016

RSC Adv., 2016,6, 106676-106679

Remote stereocontrolled asymmetric 1,6-addition/1,4-addition cascade reactions between cyclic dienones and 2-indolinethiones

X. Sun, J. Fei, C. Zou, M. Lu and J. Ye, RSC Adv., 2016, 6, 106676 DOI: 10.1039/C6RA19916J

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