Issue 7, 2014

Cytotoxic peptide–PNA conjugates obtained by RNA-programmed peptidyl transfer with turnover

Abstract

We describe a RNA-programmed peptidyl transfer reaction, which triggers the formation of a cytotoxic, cell permeant 14-mer peptide–PNA conjugate from inactive fragments. Turnover in the RNA template is required to evoke the bioactivity. HeLa cells enabled the read-out of the reaction, which proceeded rapidly when it was performed on matched RNA templates.

Graphical abstract: Cytotoxic peptide–PNA conjugates obtained by RNA-programmed peptidyl transfer with turnover

Supplementary files

Article information

Article type
Edge Article
Submitted
27 jan 2014
Accepted
18 mar 2014
First published
21 mar 2014

Chem. Sci., 2014,5, 2850-2854

Author version available

Cytotoxic peptide–PNA conjugates obtained by RNA-programmed peptidyl transfer with turnover

O. Vázquez and O. Seitz, Chem. Sci., 2014, 5, 2850 DOI: 10.1039/C4SC00299G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements