Issue 15, 2014

l-Proline catalyzed multicomponent one-pot synthesis of gem-diheteroarylmethane derivatives using facile grinding operation under solvent-free conditions at room temperature

Abstract

An efficient and straightforward L-proline catalyzed one-pot synthesis of a series of biologically relevant gem-(β-dicarbonyl)arylmethanes has been developed via a three-component reaction between indoles, aldehydes and C–H activated acids by grinding them together under solvent-free conditions at room temperature. Mild reaction conditions, high atom-economy, good yields, and eco-friendliness are some of the salient features of the present protocol.

Graphical abstract: l-Proline catalyzed multicomponent one-pot synthesis of gem-diheteroarylmethane derivatives using facile grinding operation under solvent-free conditions at room temperature

Article information

Article type
Communication
Submitted
22 ago 2013
Accepted
02 jan 2014
First published
06 jan 2014

RSC Adv., 2014,4, 7380-7388

L-Proline catalyzed multicomponent one-pot synthesis of gem-diheteroarylmethane derivatives using facile grinding operation under solvent-free conditions at room temperature

G. Brahmachari and S. Das, RSC Adv., 2014, 4, 7380 DOI: 10.1039/C3RA44568B

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