Nucleophilic opening of aryloxiranes with benzylpiperidine and subsequent rearrangement under Mitsunobu conditions led regioselectively to α-aryl-β-piperidinoalcohols and -amines. Amino-ifenprodil and indazole bioisosteres show high GluN2B affinity.
Fluorinated five-membered heterocycles have potent therapeutic activities including antiviral, anti-inflammatory, enzymatic inhibitory, and antimalarial.
Suzuki–Miyaura cross-coupling, density functional theory, and auto-docking investigations were used to determine the effectiveness and stability of indazole derivatives.
1H indazole derivatives with a ketoaryl groups at the 3-position were synthesized by a cyclisation reaction. All derivatives showed phosphorescence and/or double luminescence both in solution and the solid state.
The recent advances in the construction of N–N bond from primary and secondary amines via direct oxidation method, is an interest of both academia and industry for preparing the organic frameworks such as azos, hydrazines, indazoles and triazoles.