The review summarizes advances in the radical chemistry of polyfluorinated arenes under photocatalytic conditions. The fluoroaryl fragment serves as enabling motif for the reaction design and efficient generation of reactive intermediates.
A green and feasible synthetic protocol for α-polyfluoroarylalcohols was developed with polyfluoroarenes and alcohols via Lewis acid-assisted synergistic photoredox and hydrogen-atom transfer catalysis under batch or flow conditions.
This review summarises methods to synthesise and apply fluorine- and polyfluoroalkyl/aryl-substituted 1,2,3-triazoles. Focus is devoted to recent examples and those where the properties of both the 1,2,3-triazole and fluorine groups are important.
A general and authoritative literature overview on Pd-catalyzed cross-dehydrogenative coupling reactions of (hetero)arenes from the origins to 2023, where not only the synthetic aspects were described but also the most relevant mechanistic features.
Substrate-controlled product divergence is demonstrated in Pd-catalyzed reaction of 2-aminopyrimidines. Remote C5–H polyfluoroarylation occurs with N-alkylpyrimidine-2-amines, while N–H polyfluoroarylation is dominant for N-aryl-pyrimidine-2-amines.