Substrate-controlled product divergence is demonstrated in Pd-catalyzed reaction of 2-aminopyrimidines. Remote C5–H polyfluoroarylation occurs with N-alkylpyrimidine-2-amines, while N–H polyfluoroarylation is dominant for N-aryl-pyrimidine-2-amines.
A visible-light-driven, photoredox-catalyzed difluoromethylation, SO2 reintegration, and polyfluoroarylation cascade of conjugated dienes has been developed, employing CF2HSO2Na as a bifunctional reagent and polyfluoroarenes as terminating agents.
The review summarizes advances in the radical chemistry of polyfluorinated arenes under photocatalytic conditions. The fluoroaryl fragment serves as enabling motif for the reaction design and efficient generation of reactive intermediates.
We report a palladium-catalyzed formal C–H/C–H cross-coupling of arenes with polyfluoroarenes via aryl thianthrenium salts, resulting in the formation of a range of polyfluorinated biaryls in good to excellent yields.
Efficient photooxidation of amines by visible-light-responsive metal–organic frameworks generating α-aminoalkyl radicals to achieve halogen-atom transfer (XAT) reactions of dehalogenation, hydroalkylation and polyfluoroarylation.