A de novo zwitterionic strategy of ultra-stable chemiluminescent probes: highly selective sensing of singlet oxygen in FDA-approved phototherapy

Yao Lu, Yutao Zhang, Xia Wu, Ruihua Pu, Chenxu Yan, Weimin Liu, Xiaogang Liu, Zhiqian Guo and Wei-Hong Zhu

Chem. Sci., 2024, 15, 12431
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Phenoxy-1,2-dioxetane-based activatable chemiluminescent probes: tuning of photophysical properties for tracing enzymatic activities in living cells

Jagpreet Singh Sidhu, Gurjot Kaur, Atharva Rajesh Chavan, Mandeep K. Chahal and Rajeev Taliyan

Analyst, 2024, 149, 5739
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Cu2+-activatable fluorescence and chemiluminescence dual-mode sensing platform for visual detection of thiram

Pan Zhu, Yuanyu Tang, Yu Tang, Yating Xu, Shaojing Zhao, Chaoyi Yao, Benhua Wang, Xiangzhi Song and Minhuan Lan

Chem. Commun., 2025, 61, 11657
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A silicon rhodamine 1,2-dioxetane chemiluminophore for in vivo near-infrared imaging

Rokia Osman, Uroob Haris, Maidileyvis C. Cabello, Ralph P. Mason and Alexander R. Lippert

Org. Biomol. Chem., 2025, 23, 1846
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A two-dimensional fluorescence and chemiluminescence orthogonal probe for discriminating and quantifying similar proteins

Juan Li, Xiuyan Zhao, Yutao Zhang, Yao Lu, Haoyun Xue, Dan Li, Qiang Liu, Chenxu Yan, Weijie Chi, Xingqing Xiao, Wei-Hong Zhu and Zhiqian Guo

Chem. Sci., 2025, 16, 3228
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Non-invasive diagnosis of bacterial and non-bacterial inflammations using a dual-enzyme-responsive fluorescent indicator

Yue He, Majun Yang, Jingyi Cui, Can Zhao, Bin Jiang, Jiayun Guan, Xiaobo Zhou, Miao He, Yaya Zhen, Yuxue Zhang, Rongrong Jing, Qi Wang, Yuling Qin and Li Wu

Chem. Sci., 2024, 15, 5775
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Spirostrain-Accelerated Chemiexcitation of Dioxetanes Yields Unprecedented Detection Sensitivity in Chemiluminescence Bioassays

Rozan Tannous, Omri Shelef, Sara Gutkin, Maya David, Thomas Leirikh, Liang Ge, Qais Jaber, Qingyang Zhou, Pengchen Ma, Micha Fridman, Urs Spitz, Kendall N. Houk and Doron Shabat

ACS Cent. Sci., 2024, 10, 28
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A highly sensitive and selective chemiluminescent probe for peroxynitrite detection in vitro, in vivo and in human liver cancer tissue

Baoqu Wang, Yating Kong, Xiaoxue Tian and Min Xu

Journal of Hazardous Materials, 2024, 469, 134094
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Unprecedented Photoinduced‐Electron‐Transfer Probe with a Turn‐ON Chemiluminescence Mode‐of‐Action

Maya David, Sara Gutkin, Raj V. Nithun, Muhammad Jbara and Doron Shabat

Angewandte Chemie, 2025, 137
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Boosting Chemiexcitation of Phenoxy-1,2-dioxetanes through 7-Norbornyl and Homocubanyl Spirofusion

Sara Gutkin, Omri Shelef, Zuzana Babjaková, Laura Anna Tomanová, Matej Babjak, Tal Kopp, Qingyang Zhou, Pengchen Ma, Micha Fridman, Urs Spitz, Kendall N. Houk and Doron Shabat

JACS Au, 2024, 4, 3558
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Dihydroxanthene‐Derived Dioxetane Chemiluminophores for Activatable in Vivo Imaging

Kongke Liao, Lina Zhang, Jie Jiang, Feifei Wang and Tao Peng

Angew Chem Int Ed, 2025, 64
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High Contrast Bioimaging of Tumor and Inflammation with a Bicyclic Dioxetane Chemiluminescent Probe

Qian Shang, Shen-Huan Li, Yu-Ting He, Yun Zhang, Ting Fu, Shi-Song Han, Wenshan Huang, Xue-Qiang Wang and Jie-Hua Xu

Anal. Chem., 2024, 96, 2286
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Near‐Infrared Chemiluminescent Theranostics

Youshi Lin, Jingsheng Huang and Kanyi Pu

Angewandte Chemie, 2025, 137
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Thymidine Phosphodiester Chemiluminescent Probe for Sensitive and Selective Detection of Ectonucleotide Pyrophosphatase 1

Omri Shelef, Sara Gutkin, Molhm Nassir, Anne Krinsky, Ronit Satchi-Fainaro, Phil S. Baran and Doron Shabat

Bioconjugate Chem., 2025, 36, 152
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Near‐Infrared Chemiluminescent Theranostics

Youshi Lin, Jingsheng Huang and Kanyi Pu

Angew Chem Int Ed, 2025, 64
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Enzymes in Synergy: Bacteria Specific Molecular Probe for Locoregional Imaging of Urinary Tract Infection in vivo

Evelias Yan Hui Xin, Germain Kwek, Xiaoyu An, Caixia Sun, Songhan Liu, Ng Shuang Qing, Shonya Lingesh, Lai Jiang, Gang Liu and Bengang Xing

Angew Chem Int Ed, 2024, 63
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A chemiluminescence assay targeting granzyme A activity for monitoring inflammatory bowel disease

Jamie I. Scott, Zhiming Cheng, Emily J. Thompson, Utsa Karmakar, Verity Cowell, Maya David, Doireann Gordon, Lorena Mendive-Tapia, Alexander Le Saint-Grant, Pia Volkmer, Cher S. Chuah, Phoebe Lau, Adriano G. Rossi, Wouter B. Nagengast, Doron Shabat, Gwo-Tzer Ho and Marc Vendrell

Nat. Biomed. Eng, 2026
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Chemiexcitation Acceleration of 1,2‐Dioxetanes by Spiro‐Fused Six‐Member Rings with Electron‐Withdrawing Motifs

Maya David, Thomas Leirikh, Omri Shelef, Sara Gutkin, Tal Kopp, Qingyang Zhou, Pengchen Ma, Micha Fridman, Kendall N. Houk and Doron Shabat

Angew Chem Int Ed, 2024, 63
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Dihydroxanthene‐Derived Dioxetane Chemiluminophores for Activatable in Vivo Imaging

Kongke Liao, Lina Zhang, Jie Jiang, Feifei Wang and Tao Peng

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202514236

Phenylamine‐1,2‐Dioxetanes: Promising Class of Chemiluminescent Luminophores for Aqueous Sensing and Bacterial Detection

Maya David, Thomas Leirikh, Noa Naama, Tal Kopp and Doron Shabat

Angew Chem Int Ed, 2025, 64
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Recent advances in chemiluminescence probes for Tumor microenvironment with applications in cancer diagnosis and therapy

Dongnan Guo, Xiaofang Hou and Sicen Wang

Pharmaceutical Science Advances, 2026, 4, 100113
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Phenylamine‐1,2‐Dioxetanes: Promising Class of Chemiluminescent Luminophores for Aqueous Sensing and Bacterial Detection

Maya David, Thomas Leirikh, Noa Naama, Tal Kopp and Doron Shabat

Angewandte Chemie, 2025, 137
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Shining light on biosensors: Chemiluminescence and bioluminescence in enabling technologies

Barbara Roda, Sapna K. Deo, Gregory O'Connor, Michael Moraskie, Stefano Giordani, Valentina Marassi, Aldo Roda and Sylvia Daunert

TrAC Trends in Analytical Chemistry, 2024, 180, 117975
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Unprecedented Photoinduced‐Electron‐Transfer Probe with a Turn‐ON Chemiluminescence Mode‐of‐Action

Maya David, Sara Gutkin, Raj V. Nithun, Muhammad Jbara and Doron Shabat

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202417924

Structure–Activity Optimization of Phenoxy-1,2-dioxetane Precursors as Probes for Singlet Oxygen Yields Unprecedented Detection Sensitivity

Rozan Tannous, Tal Kopp and Doron Shabat

JACS Au, 2025, 5, 2871
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Near-infrared Emissive 1,2-Dioxetane-based Chemiluminescent Probes

Yingqi Chen, Richard Budianta and Yingying Ning

Chem. Res. Chin. Univ., 2024, 40, 806
DOI: 10.1007/s40242-024-4166-6

Chemiexcitation Acceleration of 1,2‐Dioxetanes by Spiro‐Fused Six‐Member Rings with Electron‐Withdrawing Motifs

Maya David, Thomas Leirikh, Omri Shelef, Sara Gutkin, Tal Kopp, Qingyang Zhou, Pengchen Ma, Micha Fridman, Kendall N. Houk and Doron Shabat

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202410057

Enzymes in Synergy: Bacteria Specific Molecular Probe for Locoregional Imaging of Urinary Tract Infection in vivo

Evelias Yan Hui Xin, Germain Kwek, Xiaoyu An, Caixia Sun, Songhan Liu, Ng Shuang Qing, Shonya Lingesh, Lai Jiang, Gang Liu and Bengang Xing

Angewandte Chemie, 2024, 136
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Hyper-Responsive Chemiluminescent Probe Reveals Distinct PYRase Activity in Pseudomonas aeruginosa

Rozan Tannous, Omri Shelef, Tal Kopp, Micha Fridman and Doron Shabat

Bioconjugate Chem., 2024, 35, 472
DOI: 10.1021/acs.bioconjchem.4c00015

Super-Sensitive Chemiluminescent Probe for the Detection of Caspase-3 Activity

Rozan Tannous, Chi Zhang and Doron Shabat

Bioconjugate Chem., 2025, 36, 1113
DOI: 10.1021/acs.bioconjchem.5c00151

Mechanically Triggered Bright Chemiluminescence from Polymers by Exploiting a Synergy between Masked 2-Furylcarbinol Mechanophores and 1,2-Dioxetane Chemiluminophores

Peng Liu, Yu-Ling Tseng, Liang Ge, Tian Zeng, Doron Shabat and Maxwell J. Robb

J. Am. Chem. Soc., 2024, 146, 22151
DOI: 10.1021/jacs.4c07592

Chemiluminescence-based identification and quantitative detection of pathogenic bacteria

Saisai Yan, Qing Liu, Bing Liang, Miao Zhang, Xinlin Liu, Chao Wang and Dongming Xing

Environmental Research, 2026, 288, 123228
DOI: 10.1016/j.envres.2025.123228

Sequence-activated chemiluminescence probes: programmable illumination for high-contrast in vivo sensing and imaging

Yutao Zhang, Juan Li, Wei-Hong Zhu and Zhiqian Guo

Sci. China Chem., 2025, 68, 26
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Self-luminous probes: Illuminating the path to biomedical breakthroughs

Yiyang Zhou, Shuang Huang, Shuai Huang, Ting Luo, Bin Feng, Meihui Liu and Wenbin Zeng

Talanta, 2026, 297, 128658
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Biocompatible Flash Chemiluminescent Assay Enabled by Sterically Hindered Spiro‐Strained‐Oxetanyl‐1,2‐Dioxetane

Omri Shelef, Anne Krinsky, Moriah Jospe‐Kaufman, Zuzana Babjaková, Micha Fridman, Ronit Satchi‐Fainaro, Urs Spitz and Doron Shabat

Chemistry A European J, 2024, 30
DOI: 10.1002/chem.202402981