A novel electrochemical sensor for the analysis of vibegron as a newly approved FDA drug: a rational computational design and cleaning validation application

Mahmoud A. Tantawy, Zeinab M. Goda, Suliman A. Almahmoud and Mina Wadie

Anal. Methods, 2026, 18, 881
DOI: 10.1039/D5AY02026C

Employing diaryl pyrrolone fluorescence for the sensitive spectrofluorometric determination of alfuzosin via condensation with ninhydrin and phenylacetaldehyde: Application to dosage form and spiked human plasma with greenness and blueness evaluation

Mohamed A. Abdelshakour, Al Amir S. Zaafan, Dalia M. Nagy and Sayed M. Derayea

Journal of Molecular Liquids, 2026, 450, 129529
DOI: 10.1016/j.molliq.2026.129529

Simultaneous measurement of duloxetine hydrochloride and avanafil at dual-wavelength using novel ecologically friendly TLC-densitometric method: application to synthetic mixture and spiked human plasma with evaluation of greenness and blueness

Sayed M. Derayea, Hadeer A. Elhamdy, Mohamed Oraby and Khalid M. Badr El-Din

BMC Chemistry, 2024, 18
DOI: 10.1186/s13065-024-01195-2

A novel electrochemical sensor based on reduced graphene oxide decorated with gold nanoparticles for voltammetric sensing of amlodipine in human urine

Hoda M. Marzouk, Sara El-Hanboushy, Amr M. Mahmoud, Yasmin M. Fayez, Mohamed Abdelkawy and Hayam M. Lotfy

J Appl Electrochem, 2025, 55, 813
DOI: 10.1007/s10800-024-02205-w

PLANTA Protocol for the Direct Detection and Identification of Bioactive Compounds in Complex Mixtures via Combined NMR-HPTLC-Based Heterocovariance

Vaios Amountzias, Evagelos Gikas and Nektarios Aligiannis

Anal. Chem., 2025, 97, 21843
DOI: 10.1021/acs.analchem.5c02192

An eco-intelligent smartphone-based stability-indicating HPTLC method for vibegron assay: In-silico toxicity prediction of degradation products and content uniformity application

Zeinab M. Goda, Mahmoud A. Tantawy, Suliman A. Almahmoud and Mina Wadie

Microchemical Journal, 2026, 222, 117217
DOI: 10.1016/j.microc.2026.117217

Revolutionizing digital sustainability through comparative smartphone vs. conventional HPTLC for metformin and rosuvastatin combination, with tetra-hued assessment and SDGs alignment.

Amira H. Abo-Gharam and Haydi S. Elbordiny

Microchemical Journal, 2026, 220, 116604
DOI: 10.1016/j.microc.2025.116604

Exploring sustainable analytical techniques using G score and future innovations in green analytical chemistry

Kanaka Parvathi Kannaiah and Hemanth Kumar Chanduluru

Journal of Cleaner Production, 2023, 428, 139297
DOI: 10.1016/j.jclepro.2023.139297

A multi-analyte HPTLC estimation of marker compounds in Pueraria tuberosa (Willd.) DC.: Application of AQbD approach for method optimization and greenness assessment

Mridul Kant Chaudhary, Ankita Misra and Sharad Srivastava

Microchemical Journal, 2024, 199, 109988
DOI: 10.1016/j.microc.2024.109988

Quantification of isoniazid in tablets for tuberculosis treatment by thin layer chromatography with smartphone image capture and ImageJ analysis

Mary Elizabeth Sowers, Ed Bethea, Winnie Xiao, Nidhi Phase, Christopher Harmon and David Jenkins

Microchemical Journal, 2024, 202, 110796
DOI: 10.1016/j.microc.2024.110796

A sensitive, precise, accurate, and economic planar chromatographic method developed and validated for quantification of Desidustat as per guideline

Rutvik Pandya, Heta M. Kachhiya, Dhaval Solanki, Jinal Tandel, Usmangani Chhalotiya and Dimal Shah

Separation Science Plus, 2023, 6
DOI: 10.1002/sscp.202300069

Development of a comprehensive cleaning and detoxification approach for selected sodium-glucose cotransporter-2 inhibitors including establishment of highly sensitive analytical method for their simultaneous surface residue estimation

Harish Akhare, Niraj Rajput, Tarang Jadav and Pinaki Sengupta

Microchemical Journal, 2025, 209, 112587
DOI: 10.1016/j.microc.2024.112587

A novel ultra-sensitive LC-MS/MS method for determination of elobixibat in human plasma; Application to a bioequivalence study on healthy volunteers

Mamdouh R. Rezk, Michael Soliman, Huda Shawky, Kamal A. Badr and Mina Wadie

Journal of Chromatography B, 2025, 1257, 124576
DOI: 10.1016/j.jchromb.2025.124576

Determination of Response Factors for Analytes Detected during Migration Studies, Strategy and Internal Standard Selection for Risk Minimization

Nikolaos Kritikos, Anna Bletsou, Christina Konstantinou, Antonios-Dionysios Neofotistos, Constantinos Kousoulos and Yannis Dotsikas

Molecules, 2023, 28, 5772
DOI: 10.3390/molecules28155772

Development and validation of high‐performance thin layer chromatographic method for concurrent estimation of dapagliflozin and vildagliptin in combined tablet

Ashim Kumar Sen, Satish B Khatariya, Dhanya B Sen, Rajesh A Maheshwari, Ashok H Akabari and Ramaswamy Velmurugan

Separation Science Plus, 2024, 7
DOI: 10.1002/sscp.202300132

A Novel Spectrofluorimetric Method for Vibegron in the Newly FDA Approved Pharmaceutical Formulation and in Human Plasma: Analytical QbD Strategy for Method Development and Optimization

Mina Wadie, Mahmoud A. Tantawy and Zeinab M. Goda

J Fluoresc, 2024, 35, 6653
DOI: 10.1007/s10895-024-04020-0

A novel quality-by-design assisted HPLC-DAD method for the simultaneous quantification of tryptophan, tryptophol, and voriconazole for early diagnosis and prognosis of fungal infections decoding quorum sensing phenomenon

Ahmed M. Saleh, Ola A. Saleh, Rabeay Y.A. Hassan, Amr M. Badawey and Hoda M. Marzouk

Journal of Chromatography B, 2025, 1257, 124571
DOI: 10.1016/j.jchromb.2025.124571

Recent advances and application of liquid chromatography in pharmaceutical industry

Poonam Dhull, Shashiprabha Dunuweera, Jonathan Bietsch, Raju Bandu, Chaitanya Wannere, Srinivas Achanta, Dhileep Krishnamurthy, Bo Qu and Chris Senanayake

Journal of Liquid Chromatography & Related Technologies, 2025, 48, 168
DOI: 10.1080/10826076.2024.2448692

Thin layer chromatography‒spectrodensitometric determination of a three-component mixture of propyphenazone, caffeine, ergotamine tartrate, and two of their impurities with application to tablets, spiked human plasma, and green profile assessment

Mona T. Ragab, Nesrin K. Ramadan, Nariman A. El-Ragehy and Badr A. El-Zeany

JPC-J Planar Chromat, 2023, 36, 295
DOI: 10.1007/s00764-023-00248-x

Development and Characterization of Sensitive, Eco‐Friendly, and Selective Microwave‐Aided Fluorodensitometric Probe for Estimation of Alfuzosin Using Comprehensive Approach of Multicolored Analytical Chemistry and Design of Experiments

Pintu Prajapati, Yash Patil, Anzarul Haque, Mohd Abul Kalam and Shailesh Shah

Luminescence, 2025, 40
DOI: 10.1002/bio.70372

An eco-friendly spectrophotometric analysis tool with whiteness assessment to assay erythromycin in pharmaceutical formulation through metal complexation with Ni 2+ : application to the microbiological activity using agar diffusion method

Yasser El-Shabrawy, Alaa El-din M. El-Gindy, Mary.E.K. Wahba, Aya Ayman and Aziza E Mostafa

Analytical Chemistry Letters, 2024, 14, 239
DOI: 10.1080/22297928.2024.2331141

HPTLC Combined with sHetCA and Multivariate Statistics for the Detection of Bioactive Compounds in Complex Mixtures

Vaios Amountzias, Evagelos Gikas and Nektarios Aligiannis

Molecules, 2024, 29, 6027
DOI: 10.3390/molecules29246027

Dual TLC approaches for ICU drug monitoring: A comparative study of densitometry and portable smartphone-based detection of piperacillin, tazobactam, and paracetamol

Reham A. Fekry, Khadiga M. Kelani, Maha F. Abdel-Ghany, Amr M. Mahmoud and Hend Z. Yamani

Microchemical Journal, 2026, 222, 117218
DOI: 10.1016/j.microc.2026.117218

Implementation of green analytical principles to develop and validate the HPLC method for the separation and identification of degradation products of Panobinostat, and its characterization by using LC-QTOF-MS/MS and its in-silico toxicity prediction using ADMET software

Vijay Nayak Bhukya and Durga Prasad Beda

Green Analytical Chemistry, 2024, 8, 100090
DOI: 10.1016/j.greeac.2023.100090

New method for rapid detection and simultaneous determination of prohibited adrenergic drugs in sports using thin layer chromatography and image processing

Eda Büker, Dorina Casoni, Melinda Carmen Szasz and Simona Codruța Aurora Cobzac

Journal of Liquid Chromatography & Related Technologies, 2024, 47, 360
DOI: 10.1080/10826076.2024.2386320

Quality assessment, HPTLC-DPPH, analytical quality by design based HPTLC method development for estimation of piperine in piper species and marketed formulations

Amruta Balekundri, Pramod J Hurkadale and Harsha Hegde

Green Analytical Chemistry, 2024, 8, 100093
DOI: 10.1016/j.greeac.2024.100093

State-of-the-art mathematically induced filtration approaches for smart spectrophotometric assessment of silodosin and solifenacin mixture in their new challenging formulation: Multi-tool greenness and whiteness evaluation

Yasmin Rostom, Mamdouh R. Rezk, Mina Wadie, Ezzat M. Abdel-Moety and Hoda M. Marzouk

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2024, 307, 123650
DOI: 10.1016/j.saa.2023.123650

A greener RP-HPTLC-densitometry method for the quantification of apremilast in nanoformulations and commercial tablets: Greenness assessment by analytical eco-scale, ChlorTox, and AGREE methods

Faiyaz Shakeel, Prawez Alam, Mohammed H. Alqarni, Muzaffar Iqbal, Md. Khalid Anwer and Sultan Alshehri

Arabian Journal of Chemistry, 2024, 17, 105571
DOI: 10.1016/j.arabjc.2023.105571

Simultaneous determination of lesinurad and febuxostat in commercial fixed-dose combinations using a greener normal-phase HPTLC method

Prawez Alam, Faiyaz Shakeel, Sultan Alshehri, Muzaffar Iqbal, Ahmed I. Foudah, Tariq M. Aljarba, Fatma M. Abdel Bar and Mohammed H. Alqarni

Green Processing and Synthesis, 2024, 13
DOI: 10.1515/gps-2023-0264

Development of an HPLC–UV method for quantification of posaconazole in low-volume plasma samples: design of experiments and machine learning models

Fereshteh Bayat, Ali Hashemi Baghi, Zahra Abbasian, Simin Dadashzadeh, Reza Aboofazeli and Azadeh Haeri

BMC Chemistry, 2024, 18
DOI: 10.1186/s13065-024-01349-2

A densitometric HPTLC method for the simultaneous quali-quantitative determination of rosavin and salidroside in Rhodiola rosea L. based commercial products: A quick screening by HPTLC-based fingerprint and antioxidant evaluation

Simonetta Gemma, Giuseppina Multari, Laura Turco and Francesca Romana Gallo

Journal of Liquid Chromatography & Related Technologies, 2025, 48, 282
DOI: 10.1080/10826076.2025.2462263

Robust method operable design region for economical and eco‐friendly chromatographic analysis of azilsartan medoxomil and cilnidipine by incorporating a hybrid approach of green analytical chemistry and analytical quality by design

Pintu Prajapati, Abhinandan Shahi, Aneri Acharya, Veerashakar Pulusu and Shailesh Shah

Separation Science Plus, 2023, 6
DOI: 10.1002/sscp.202300111

Development of an effective cleaning technique and ancillary analytical method for estimation of residues of selected kinase inhibitors from stainless steel and glass surfaces by swab sampling

Vishal Vasant Borale, Niraj Rajput, Tarang Jadav, Pooja Dhakne, Megha Pillai, Nitish Sharma and Pinaki Sengupta

Journal of Pharmaceutical and Biomedical Analysis, 2024, 242, 116024
DOI: 10.1016/j.jpba.2024.116024

Evaluation of analytical greenness metric for an eco-friendly method developed through the integration of green chemistry and quality-by-design for the simultaneous determination of Nebivolol hydrochloride, Telmisartan, Valsartan, and Amlodipine besylate

Y.V.S. Veerendra, Pradeep Kumar Brahman, Sharad D. Mankumare, Jayaraju Ch and Vinod Kumar C

Heliyon, 2024, 10, e35376
DOI: 10.1016/j.heliyon.2024.e35376

Stability indicating HPTLC – densitometric method for estimation of vonoprazan fumarate

Mitalben S. Parmar, Dimal A. Shah and Usmangani K. Chhalotiya

Drug Development and Industrial Pharmacy, 2025, 51, 546
DOI: 10.1080/03639045.2025.2492192

A novel eco-friendly HPLC method with dual detection modes for versatile quantification of dutasteride and silodosin in pharmaceutical formulation, dissolution testing and spiked human plasma

Mina Wadie, Ezzat M. Abdel-Moety, Mamdouh R. Rezk and Hoda M. Marzouk

Microchemical Journal, 2024, 197, 109753
DOI: 10.1016/j.microc.2023.109753

Development of a Low‐Cost Method for the Determination of Stabilizers in Smokeless Propellants Using Thin‐Layer Chromatography and Image Densitometry

José Daniel Langendorf da Silva, Namir Halilović, Valdir Florêncio da Veiga Junior, Rodrigo Leonard Barbosa Rodrigues and Fernando Cunha Peixoto

Propellants Explo Pyrotec, 2025, 50, 144
DOI: 10.1002/prep.12069

An High Performance Thin Layer Chromatography (HPTLC) Validated Method for the Determination of Ephedrine Alkaloids in Multi-Plant Formulations

Simonetta Gemma, Giuseppina Multari and Francesca R Gallo

Journal of Chromatographic Science, 2025, 63
DOI: 10.1093/chromsci/bmaf020

A green and versatile HPLC-DAD method for determination of silodosin and solifenacin in their newly combined formulation: Evaluation of content uniformity and dissolution profiles

Mina Wadie, Ezzat M. Abdel-Moety, Mamdouh R. Rezk and Hoda M. Marzouk

Sustainable Chemistry and Pharmacy, 2025, 44, 101923
DOI: 10.1016/j.scp.2025.101923

HPTLC method to support formulation development and quality control of the tablets prepared from fruit extracts of Piper longum

Kunjan B. Bodiwala, Jahanvi Kataria and Jayant Dave

Natural Product Research, 2026, 40, 481
DOI: 10.1080/14786419.2024.2413428

Eco-Friendly Simultaneous Estimation of Ponceau 4R and Carmoisine Employing an Analytical Quality by Design-Aided RP-HPLC Method in Commercial Food Samples Utilizing a Green Ultrasound-Assisted Extraction Technique

Atyurmila Chakraborty and Kavitha Jayaseelan

Journal of AOAC International, 2024, 107, 430
DOI: 10.1093/jaoacint/qsae020

Simultaneous estimation of ibuprofen, caffeine, and paracetamol in commercial products using a green reverse-phase HPTLC method

Mohammed Hamed Alqarni, Faiyaz Shakeel, Sultan Alshehri, Ahmed Ibrahim Foudah, Tariq Mohammed Aljarba, Fatma Mohamed Abdel Bar and Prawez Alam

Green Processing and Synthesis, 2024, 13
DOI: 10.1515/gps-2023-0220