Structural elucidation and anti-nonalcoholic fatty liver disease activity of Polygonatum cyrtonema Hua polysaccharide

Wei Liu, Taili Shao, Lei Tian, Zhengrui Ren, Lan Gao, Zhiyan Tang, Zheng Fang, Pingchuan Yuan, Chunyan Liu, Jikun Li, Guodong Wang and Jun Han

Food Funct., 2022, 13, 12883
DOI: 10.1039/D2FO03384D

Tangshen formula targets the gut microbiota to treat non-alcoholic fatty liver disease in HFD mice: A 16S rRNA and non-targeted metabolomics analyses

Shaopeng Wang, Xin Li, Bo Zhang, Yuxi Li, Kexu Chen, Huimin Qi, Mengqi Gao, Jin Rong, Lin Liu, Yuzhou Wan, Xi Dong, Meihua Yan, Liang Ma, Ping Li and Tingting Zhao

Biomedicine & Pharmacotherapy, 2024, 173, 116405
DOI: 10.1016/j.biopha.2024.116405

Research Progress on the Therapeutic Effect of Polysaccharides on Non-Alcoholic Fatty Liver Disease through the Regulation of the Gut–Liver Axis

Xiang Chen, Menghan Liu, Jun Tang, Ning Wang, Yibin Feng and Haotian Ma

IJMS, 2022, 23, 11710
DOI: 10.3390/ijms231911710

Seabuckthorn polysaccharides mitigate hepatic steatosis by modulating the Nrf-2/HO-1 pathway and gut microbiota

Yan Yan, Haisheng Yuan, Fan Yang, Heiya Na, Xiuling Yu, Jingran Liu and Yuzhen Wang

AMB Expr, 2024, 14
DOI: 10.1186/s13568-024-01756-7

Metabolite-mediated crosstalk: unraveling the interactions between gut microbiota and host in fatty liver hemorrhagic syndrome of laying hens

Shaobo Zhang, Xinghua Zhao, Xin He, Wanyu Shi and Ning Ma

J Animal Sci Biotechnol, 2026, 17
DOI: 10.1186/s40104-025-01319-1

Astragalus mongholicus polysaccharides alleviate insulin resistance through modulation of PI3K/AKT, TLR4/NF-kB signaling pathway and microbiota in rats with Type 2 Diabetes Mellitus

Haisheng Yuan, Guoquan Xu, Jingran Liu, Yan Yan, Shimin Zhao, Fujuan Cai, Xiuling Yu, Yuzhen Wang and Minhui Li

Journal of Traditional and Complementary Medicine, 2025, 15, 274
DOI: 10.1016/j.jtcme.2024.05.007

Astragalus polysaccharide mitigates transport stress-induced hepatic metabolic stress via improving hepatic glucolipid metabolism in chicks

Bi-Chen Zhao, Yi-Xi Tang, Bai-Hao Qiu, Hao-Liang Xu, Tian-Hao Wang, Ahmed Ibrahim Ahmed Elsherbeni, Hassan Bayoumi Ali Gharib and Jin-Long Li

Journal of Animal Science, 2022, 100
DOI: 10.1093/jas/skac244

Chitosan-Stabilized Selenium Nanoparticles Alleviate High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease (NAFLD) by Modulating the Gut Barrier Function and Microbiota

Yuhang Luo, Shujiang Peng, Jintao Cheng, Hongli Yang, Lin Lin, Guiling Yang, Yuanxiang Jin, Qingchi Wang and Zhengshun Wen

JFB, 2024, 15, 236
DOI: 10.3390/jfb15080236

Potential protective role of Lycium ruthenicum Murray polysaccharides against lipopolysaccharide-induced liver injury via mitochondrial biogenesis

Wenjia Wang, Desheng Wu, Jiaguo Liu and Danchen Aaron Yang

International Journal of Biological Macromolecules, 2025, 306, 141365
DOI: 10.1016/j.ijbiomac.2025.141365

Phosphorylation: new star of pathogenesis and treatment in steatotic liver disease

Tiansu Lv, Yan Lou, Qianhua Yan, Lijuan Nie, Zhe Cheng and Xiqiao Zhou

Lipids Health Dis, 2024, 23
DOI: 10.1186/s12944-024-02037-9

Structural elucidation of an active arabinoglucan from Gomphrena globosa and its protection effect and mechanism against metabolic dysfunction-associated steatohepatitis

Meilin Chen, Jianing Zong, Fei He, Wanqi Zhou, Renjie Liu, Haoran Xia, Mengfei Mao, Can Jin, Kaiping Wang and Kan Ding

Carbohydrate Polymers, 2025, 348, 122860
DOI: 10.1016/j.carbpol.2024.122860

The Role of Traditional Chinese Medicine in the Management of Nonalcoholic Fatty Liver Disease: Targeting Gut Microbiome

Yifan Zhang, Hongkun Li, Na Jiang and Qingjing Ru

Am. J. Chin. Med., 2025, 53, 2103
DOI: 10.1142/S0192415X25500788

The traditional Chinese medicine and non-small cell lung cancer: from a gut microbiome perspective

Xuelin Wang, Liming Hou, Meng Cui, Junnan Liu, Mengzhou Wang and Jianwu Xie

Front. Cell. Infect. Microbiol., 2023, 13
DOI: 10.3389/fcimb.2023.1151557

Exploring the Regulatory Effect of Tegillarca granosa Polysaccharide on High‐Fat Diet‐Induced Non‐Alcoholic Fatty Liver Disease in Mice Based on Intestinal Flora

Xingwen Yang, Shiwei Yao, Qihong Jiang, Hui Chen, Shulai Liu, Guoxin Shen, Xingwei Xiang and Lin Chen

Molecular Nutrition Food Res, 2024, 68
DOI: 10.1002/mnfr.202300453

Study on the Effects of a Compound Preparation of Hirsutella sinensis-Rhodiola-Ganoderma lucidum on Immune Function in Mice

云鹏王

HJFNS, 2026, 15, 1
DOI: 10.12677/hjfns.2026.151001

Health benefits of medicinal plant natural products via microbiota-mediated different gut axes

Xiang Li, Yufan Liu, Ning Liu, Hanning Wu, Kexin Cong, Linnan Duan, Tianli Chen and Jie Zhang

Pharmacological Research, 2025, 215, 107730
DOI: 10.1016/j.phrs.2025.107730

Biochemical changes associated with non-alcoholic fatty liver disease in response to berberine treatment: a systematic review and meta-analysis of clinical and preclinical research

Wenyu Zhu, Lele Yang, Yufan Dai, Hanyang Wang, Jiaxuan Zhou, Lina Xia and Tao Shen

Front. Pharmacol., 2025, 16
DOI: 10.3389/fphar.2025.1460643

Potential Effects of Functional Foods and Dietary Supplements on Metabolic-Associated Fatty Liver Disease and the Underlying Mechanisms: A Narrative Review with a Focus on the Modulation of the Gut Microbiota

Zukang Chang, Xiaoxue Xu, Yujia Xu, Xue Wei, Gangao Yang, Pingping Guo, Jinghan Jia, Yongning Chen, XinHua Song, Yanfei Zheng, Wenlong Sun and Lingru Li

J. Agric. Food Chem., 2025, 73, 29247
DOI: 10.1021/acs.jafc.5c05587

Interactions between Gut Microbiota and Natural Bioactive Polysaccharides in Metabolic Diseases: Review

Yu Pi, Miaoyu Fang, Yanpin Li, Long Cai, Ruyi Han, Wenjuan Sun, Xianren Jiang, Liang Chen, Jun Du, Zhigang Zhu and Xilong Li

Nutrients, 2024, 16, 2838
DOI: 10.3390/nu16172838

Acupuncture ameliorates synovitis in mice with collagen-induced arthritis by repressing ferroptosis via butyric acid

Chenlu Huo, Shuang Li, Anting Liu, Yujie Hong and Yan Zhu

International Immunopharmacology, 2024, 143, 113342
DOI: 10.1016/j.intimp.2024.113342

Gut microbiota: A magical multifunctional target regulated by medicine food homology species

Wei-Fang Zuo, Qiwen Pang, Lai-Ping Yao, Yang Zhang, Cheng Peng, Wei Huang and Bo Han

Journal of Advanced Research, 2023, 52, 151
DOI: 10.1016/j.jare.2023.05.011

Polydatin: a potential NAFLD therapeutic drug that regulates mitochondrial autophagy through SIRT3-FOXO3-BNIP3 and PINK1-PRKN mechanisms - a network pharmacology and experimental investigation

Jing He, Yi-cai Qian, Ying-chuan Yin, Jing-rui Kang and Tian-rong Pan

Chemico-Biological Interactions, 2024, 398, 111110
DOI: 10.1016/j.cbi.2024.111110

Raspberry polysaccharides attenuate hepatic inflammation and oxidative stress in diet-induced obese mice by enhancing butyrate-mediated intestinal barrier function

Mengjun Wu, Yuxin Lyu, Hangying Xu, Hanqi Luo, Xiaoli Yin and Hong Zheng

International Journal of Biological Macromolecules, 2024, 262, 130007
DOI: 10.1016/j.ijbiomac.2024.130007

The molecular mechanism of polysaccharides in combating major depressive disorder: A comprehensive review

Hongwei Kong, Tianren Xu, Shengguang Wang, Zhiyuan Zhang, Min Li, Suyan Qu, Qinqing Li, Peng Gao and Zhufeng Cong

International Journal of Biological Macromolecules, 2024, 259, 129067
DOI: 10.1016/j.ijbiomac.2023.129067

Recent advances in the modulatory effects and mechanisms of food-derived polysaccharides on hepatic lipid metabolic dysfunction

Yue Zhang, Qing Chen, Zhi Ouyang, Hao Dong, Chao Li and Xiong Fu

International Journal of Biological Macromolecules, 2025, 334, 149104
DOI: 10.1016/j.ijbiomac.2025.149104

Identification of key genes involved in the alleviative effects of Polysaccharide of Atractylodes macrocephala Koidz on high-fat diet-induced nonalcoholic fatty liver disease in mice

Xiaoxiao Chen, Shuzhan Yang, Haiqiong Yu, Xinliang Fu, Wanyan Li, Bingxin Li, Cheng Fu, Xuezhen Cao, Danning Xu and Nan Cao

Journal of Functional Foods, 2024, 116, 106201
DOI: 10.1016/j.jff.2024.106201

PAMK Ameliorates Non-Alcoholic Steatohepatitis and Associated Anxiety/Depression-like Behaviors Through Restoring Gut Microbiota and Metabolites in Mice

Jianmei Yang, Wanyi Ou, Guiru Lin, Yuanfei Wang, Dongliang Chen, Ze Zeng, Zumin Chen, Xiaomin Lu, Aiping Wu, Chenli Lin and Yinji Liang

Nutrients, 2024, 16, 3837
DOI: 10.3390/nu16223837

RETRACTED: Astragalus polysaccharide reduces the severity of acute pancreatitis under a high-fat diet through enriching L. reuteri and propionate

Qiang Wang, Xuxu Liu, Zhiwei Du, Yi Zheng, Ziang Meng, Zhenyi Lv, Liyi Wang and Dongbo Xue

International Journal of Biological Macromolecules, 2025, 298, 140021
DOI: 10.1016/j.ijbiomac.2025.140021

Effects of plant natural products on metabolic-associated fatty liver disease and the underlying mechanisms: a narrative review with a focus on the modulation of the gut microbiota

Tianqi Cai, Xinhua Song, Xiaoxue Xu, Ling Dong, Shufei Liang, Meiling Xin, Yuhong Huang, Linghui Zhu, Tianxing Li, Xueke Wang, Yini Fang, Zhengbao Xu, Chao Wang, Meng Wang, Jingda Li, Yanfei Zheng, Wenlong Sun and Lingru Li

Front. Cell. Infect. Microbiol., 2024, 14
DOI: 10.3389/fcimb.2024.1323261

Structural analysis and treatment of acute liver injury of polysaccharides from the Radix Actinidiae Chinensis

Zhongpeng Ding, Qianyi Ying, Jing Lei, Ningchen Zhang, Yu Xia, Yilin Du, Beihua Xu and Senlin Shi

Front. Pharmacol., 2025, 16
DOI: 10.3389/fphar.2025.1544302

Targeting the gut microbiota and lipid metabolism: potential mechanisms of natural products for the treatment of non-alcoholic fatty liver disease

Yutian Zhang, Tianlin Wang, Junquan Han, Jielin Song, Chaoshuai Yang, Lei Liang, Huizhen Li and Hong Wang

Front. Pharmacol., 2025, 16
DOI: 10.3389/fphar.2025.1610498

Preparation of hierarchically targetable Astragalus polysaccharide lipid nanoparticles and study on their therapeutic effect on orthotopic colon cancer

Yan Hou, Jinjia Wu, Bing Jin, Yun Zhang, Jinlan Zhang, Yinghua Zhang, Jia Gao, Xiaobo Sun and Zhengqi Dong

Materials Today Bio, 2025, 35, 102509
DOI: 10.1016/j.mtbio.2025.102509

Effects of traditional Chinese medicine polysaccharides on chronic diseases by modulating gut microbiota: A review

Xinyu Li, Riran Zhu, Qian Liu, Henglai Sun, Huagang Sheng and Liqiao Zhu

International Journal of Biological Macromolecules, 2024, 282, 136691
DOI: 10.1016/j.ijbiomac.2024.136691

Gut microbiota modulation by Traditional Chinese Medicine: a translational strategy for metabolic dysfunction-associated steatotic liver disease

Ting Zhou, Ziwen Jin, Rilei Jiang and Weiwei Li

Front. Pharmacol., 2025, 16
DOI: 10.3389/fphar.2025.1600439

Mechanistic Investigation of Astragalus Root in the Management of T2DM-NAFLD Comorbidity: An Integrated Network Pharmacology, Molecular Docking, Molecular Dynamics Simulation, and In Vitro Study

Jie Li, Nanqi Shao, Ying Gao, Baojian Li, Yan Liang, Yinglai Yang and Jianguang Li

Pharmaceuticals, 2026, 19, 289
DOI: 10.3390/ph19020289

Dietary Qi-Weng-Huangbo powder enhances growth performance, diarrhoea and immune function of weaned piglets by modulating gut health and microbial profiles

Chuanpi Xiao, Kai Li, Chunran Teng, Zeou Wei, Jiaheng Li, Shunfeng Zhang, Lei Liu, Huiyuan Lv and Ruqing Zhong

Front. Immunol., 2023, 14
DOI: 10.3389/fimmu.2023.1342852

From nonalcoholic fatty liver disease to neuroinflammation: the role of chronic systemic inflammation

Xupeng Huang, Ziqi Sang, Haifeng Liu, Jia Yang, Kuisong Wang, Yanan Qu and Houbo Deng

Metab Brain Dis, 2025, 40
DOI: 10.1007/s11011-025-01669-9

The Gut-Liver Axis in NAFLD Progression: Insights into Pathogenesis and Therapeutic Opportunities

Kartik Dubey and Dr. Rachana Singh

IJARSCT, 2024, 537
DOI: 10.48175/IJARSCT-18773

Polysaccharides Extracted from Old Stalks of Asparagus officinalis L. Improve Nonalcoholic Fatty Liver by Increasing the Gut Butyric Acid Content and Improving Gut Barrier Function

Wenlong Sun, Jinghan Jia, Guangpeng Liu, Shufei Liang, Yuhong Huang, Meiling Xin, Zukang Chang, Xingxing Liu, Chao Ma, Xinhua Song, Fatao He, Yuanda Song and Maoyu Wu

J. Agric. Food Chem., 2025, 73, 6632
DOI: 10.1021/acs.jafc.4c07078

Preclinical pharmacokinetics-related pharmacological effects of orally administered polysaccharides from traditional Chinese medicines: A review

Dan Ye, Qing Zhao, Ding Ding and Bing-Liang Ma

International Journal of Biological Macromolecules, 2023, 252, 126484
DOI: 10.1016/j.ijbiomac.2023.126484

Advancements in research on the anti-metabolic dysfunction-associated steatotic liver disease effects and mechanisms of action of traditional Chinese medicine polysaccharides: A review

Zhiying Bian, Anhui Zhao, Qinghe Wang, Yaoguang Li, Yixin Liu, Wenjing Yang, Yong Li, Jing Bai, Shuqi Niu, Sijing Liu and Jinlin Guo

International Journal of Biological Macromolecules, 2025, 321, 146292
DOI: 10.1016/j.ijbiomac.2025.146292

Metabolic dysfunction‑associated steatotic liver disease: Pathogenesis, model and treatment (Review)

Qinge Ma, Kejia Liu, Chenyu Chang, Lei Wang, Zhangyang Shen, Jiaxin Li, Mozili Adu, Qingyuan Lin, Huilian Huang, Xutao Wu and Rongrui Wei

Int J Mol Med, 2025, 56, 1
DOI: 10.3892/ijmm.2025.5668

Maternal Folic Acid Supplementation during Pregnancy Prevents Hepatic Steatosis in Male Offspring of Rat Dams Fed High-Fat Diet, Which Is Associated with the Regulation of Gut Microbiota

Huaqi Zhang, Yutong Wang, Xinyu Zhang, Li Zhang, Xuenuo Zhao, Yan Xu, Peng Wang, Xi Liang, Meilan Xue and Hui Liang

Nutrients, 2023, 15, 4726
DOI: 10.3390/nu15224726

Molecular Mechanism Pathways of Natural Compounds for the Treatment of Non-Alcoholic Fatty Liver Disease

Xiaolei Fang, Jiayu Song, Kaixuan Zhou, Xue Zi, Bin Sun, Huiwei Bao and Lijing Li

Molecules, 2023, 28, 5645
DOI: 10.3390/molecules28155645

Exploring the immunometabolic potential of Danggui Buxue Decoction for the treatment of IBD-related colorectal cancer

Yang Zhang, Qianming Kang, Luying He, Ka Iong Chan, Hui Gu, Wenjing Xue, Zhangfeng Zhong and Wen Tan

Chin Med, 2024, 19
DOI: 10.1186/s13020-024-00978-y

Astragalus polysaccharide protects sepsis model rats after cecum ligation and puncture

Jun Li, Jie Zhao, Yihui Chai, Wen Li, Xiaoqing Liu and Yunzhi Chen

Front. Bioeng. Biotechnol., 2022, 10
DOI: 10.3389/fbioe.2022.1020300

Intestinal flora: A new target for traditional Chinese medicine to improve lipid metabolism disorders

Min Liu, Wei Shi, Yefang Huang, Yeke Wu and Keming Wu

Front. Pharmacol., 2023, 14
DOI: 10.3389/fphar.2023.1134430

Targeting AMPK related signaling pathways: A feasible approach for natural herbal medicines to intervene non-alcoholic fatty liver disease

Yongqing Cai, Lu Fang, Fei Chen, Peiling Zhong, Xiangru Zheng, Haiyan Xing, Rongrong Fan, Lie Yuan, Wei Peng and Xiaoli Li

Journal of Pharmaceutical Analysis, 2025, 15, 101052
DOI: 10.1016/j.jpha.2024.101052

Screening of Herbs with Potential Modulation of NLRP3 Inflammasomes for Acute Liver Failure: A Study Based on the Herb-Compound-Target Network and the ssGSEA Algorithm

Haiya Ou, Susu Qiu, Xiaopeng Ye and Xiaotong Wang

CTMC, 2025, 25, 318
DOI: 10.2174/0115680266331775241024064136

Modulatory effect of camel milk on intestinal microbiota of mice with non-alcoholic fatty liver disease

Shiqi Hao, Liang Ming, Yafei Li, Haodi Lv, Lin Li, Tuyatsetseg Jambal and Rimutu Ji

Front. Nutr., 2022, 9
DOI: 10.3389/fnut.2022.1072133

Glucose deposited during goose fatty liver formation inhibits inflammation in goose fatty liver by reducing the interaction between PKA and IκB

Mengqing Lv, Jiahui Li, Ya Xing, Xiaoyi Zhou, Jing Ge, Tuoyu Geng, Daoqing Gong and Minmeng Zhao

Poultry Science, 2025, 104, 105515
DOI: 10.1016/j.psj.2025.105515

Preventive and therapeutic effects of natural products and herbal extracts onnonalcoholic fatty liver disease/nonalcoholic steatohepatitis

Yiming Cao, Xiaoxue Fang, Mingyang Sun, Yegang Zhang, Mengyao Shan, Xintian Lan, Difu Zhu and Haoming Luo

Phytotherapy Research, 2023, 37, 3867
DOI: 10.1002/ptr.7932

Huajuxiaoji Formula Alleviates Phenyl Sulfate‐Induced Diabetic Kidney Disease by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis

Zeng Zhang, Yueping Bi, Fengzhu Zhou, Duanchun Zhang, Siyu Xu, Xinyi Zhang, Zhaohua Fan, Zheng Yao, Yanming He and Carla Iacobini

Journal of Diabetes Research, 2024, 2024
DOI: 10.1155/2024/8772009

Characteristic of different thermal treatment-induced dough protein oxidation and its impact on human gut microbiota

Yuhui Yang, Yanli Xie, Ru Liu, Xiaojie Cui, Changtong Cui, Qiaofen Cheng, Peng Li and Renyong Zhao

Current Research in Food Science, 2026, 12, 101357
DOI: 10.1016/j.crfs.2026.101357

Traditional herbs: mechanisms to combat cellular senescence

Lei Wang, Jiahui Wang, Zhihui Yang, Yue Wang, Tiejian Zhao, Weisheng Luo, Tianjian Liang and Zheng Yang

Aging, 2023, 15, 14473
DOI: 10.18632/aging.205269

Research progress on the therapeutic effects of polysaccharides on non-alcoholic fatty liver diseases

Yu-long Hu, Qiaoli Ma, Xiaoqiang Dong, Yuanfang Kong, Juntao Cai, Jieming Li and Chunhong Dong

Front. Nutr., 2023, 10
DOI: 10.3389/fnut.2023.1107551

Targeting G-protein-coupled receptors and gut microbiota: Ge-Lian Qi-Shen decoction elevates GLP-1 to combat non-alcoholic fatty liver disease

Menglei Ding, Zihan Xiao, Xionglin Hou, Zichen Luo, Zepeng Zhang, Manman Guo, Cheng Xu, Ruimin Xu, Jinjun Shan and Huiping Peng

Chin Med, 2026, 21
DOI: 10.1186/s13020-025-01305-9

Progress on the Anti-Inflammatory Activity and Structure–Efficacy Relationship of Polysaccharides from Medical and Edible Homologous Traditional Chinese Medicines

Yuanyuan Zhang, Xiulian Lin, Li Xia, Suhui Xiong, Bohou Xia, Jingchen Xie, Yan Lin, Limei Lin and Ping Wu

Molecules, 2024, 29, 3852
DOI: 10.3390/molecules29163852

Assessment of Auricularia cornea var. Li. polysaccharides potential to improve hepatic, antioxidation and intestinal microecology in rats with non-alcoholic fatty liver disease

Tiantian Zhou, Xue Mao, Wei Jiang, Yu Pan, Xijun Chen, Jihua Hu, Xianghui Kong and Haihua Xia

Front. Nutr., 2023, 10
DOI: 10.3389/fnut.2023.1161537

Polysaccharides: The Potential Prebiotics for Metabolic Associated Fatty Liver Disease (MAFLD)

Qin Guo, Yun Li, Xin Dai, Bangmao Wang, Jie Zhang and Hailong Cao

Nutrients, 2023, 15, 3722
DOI: 10.3390/nu15173722

Gut microbiota–NLRP3 inflammasome crosstalk in metabolic dysfunction-associated steatotic liver disease

Tingting Yu, Lei Luo, Juan Xue, Wenqian Tang, Xiaojie Wu and Fan Yang

Clinics and Research in Hepatology and Gastroenterology, 2024, 48, 102458
DOI: 10.1016/j.clinre.2024.102458

Gut Microbiota-Targeted Therapeutics for Metabolic Disorders: Mechanistic Insights into the Synergy of Probiotic-Fermented Herbal Bioactives

Yue Fan, Yinhui Liu, Chenyi Shao, Chunyu Jiang, Lijuan Wu, Jing Xiao and Li Tang

IJMS, 2025, 26, 5486
DOI: 10.3390/ijms26125486

Bridging Traditional Chinese Medicine and Modern Science: The Gut-Zang-Fu Axis and its Scientific Advances

Zhe-Xin Ni, Nan Zhang, Wei Zhou and Yue Gao

World Journal of Traditional Chinese Medicine, 2026
DOI: 10.4103/wjtcm.wjtcm_68_25

The Effect of Astragalus mongholicus Water Extract on Urinary Function in Rats

Qinhu Zhang, Yun Jiang, Wei Jiang, Huanmin Qu, Jianbin Cheng, Xuanhui Dai and Qianfeng He

j biobased mat bioenergy, 2024, 18, 878
DOI: 10.1166/jbmb.2024.2420

Pretreatment with Astragalus polysaccharide alleviates heat stroke–induced intestinal injury in mice

Niqi Shan, Linxiao Wang, Chujun Duan, Yilin Wu, Yangmengjie Jing, Hanyin Fan, Shuai Wang, Yuling Wang, Shijia Wang, Hui Liu, Kun Cheng, Lin Liu, Shanshou Liu and Ran Zhuang

Front. Pharmacol., 2025, 16
DOI: 10.3389/fphar.2025.1612852

Ziziphi Spinosae Semen jujubosides extract ameliorates cognitive impairment by modulating brain BDNF/TrkB pathways and intestinal barrier integrity in HFD-fed mice

Shan Jia, Taofu Tu, Hong Yuan, Fengchen Li, Xiaoyu Wang, Yonghong Meng and Yalong Lu

Food Bioscience, 2025, 74, 107865
DOI: 10.1016/j.fbio.2025.107865

Polysaccharide-mediated modulation of gut microbiota in the treatment of liver diseases: Promising approach with significant challenges

Yang Yang, Guifang Fan, Jianhang Lan, Xin Li, Xiaojiaoyang Li and Runping Liu

International Journal of Biological Macromolecules, 2024, 280, 135566
DOI: 10.1016/j.ijbiomac.2024.135566

Astragaloside-IV promotes autophagy via the Akt/mTOR pathway to improve cellular lipid deposition

Guo Liu, Ye-Hui Wang, Ting Zhang, Ya-Qiong Li, Xin-Yue Chen, Wei Dong, Wei Li, Qi-Xiang Miao, Wen-Bo Qiao, Hui-Qiang Tian and Shi-Long Yin

Medicine, 2024, 103, e37846
DOI: 10.1097/MD.0000000000037846

Targeting regulation of lipid metabolism with polysaccharide of traditional Chinese medicine for the treatment of non-alcoholic fatty liver disease: A review

Wei Liu, Meng Sun, Hao Zhang, Wen-Ting Wang, Jian Song, Meng-Yang Wang, Chun-Mei Wang and Hai-Ming Sun

International Journal of Biological Macromolecules, 2025, 306, 141660
DOI: 10.1016/j.ijbiomac.2025.141660

Research Progress on Chemical Components of Astragalus membranaceus and Treatment of Metabolic Syndrome

Taiyu Liu, Yumu Sun and Xueying Zhao

Molecules, 2025, 30, 3721
DOI: 10.3390/molecules30183721

The effects and mechanisms of Xiaoyao San on nonalcoholic fatty liver disease rat based on transcriptomics and proteomics analysis

Yunxiao Liu, Shuanghu Wang, Ayesha Younas, Jiaojian Lv, Abdullah Al Mamun and Chuxiao Shao

Sci Rep, 2025, 15
DOI: 10.1038/s41598-025-91890-4

A Natural Compound Methylnissolin: Physicochemical Properties, Pharmacological Activities, Pharmacokinetics and Resource Development

Ziyang Lin, Mingjie Liang, Xianlong Zhang, Zhuo Cen, Fengxin Kang, Baien Liang, Ying Lai, Minyi Li, Tingting Duan, Junzheng Yang and Bo Liu

DDDT, 2025, Volume 19, 3763
DOI: 10.2147/DDDT.S518508

Enhancement of biochemical and genomic pathways through lycopene-loaded nano-liposomes: Alleviating insulin resistance, hepatic steatosis, and autophagy in obese rats with non-alcoholic fatty liver disease: Involvement of SMO, GLI-1, and PTCH-1 genes

Gamal A. Salem, Amany Abdel-Rahman Mohamed, Safaa I. Khater, Ahmed E. Noreldin, Manal Alosaimi, Wafa S. Alansari, Ghalia Shamlan, Areej A. Eskandrani, Marwa Mahmoud Awad, Rehab Ahmed Ahmed El-Shaer, Mohamed A. Nassan, Mahmoud Mostafa and Tarek Khamis

Gene, 2023, 883, 147670
DOI: 10.1016/j.gene.2023.147670

Gut microbiota: The key to the treatment of metabolic syndrome in traditional Chinese medicine – a case study of diabetes and nonalcoholic fatty liver disease

Yang Bao, Xiao Han, Da Liu, Zhaolin Tan and Yongzhi Deng

Front. Immunol., 2022, 13
DOI: 10.3389/fimmu.2022.1072376

Lactobacillus plantarumHF02 alleviates lipid accumulation and intestinal microbiota dysbiosis in high‐fat diet‐induced obese mice

Haoran Chen, Haiding Zhao, Xiaofen Qi, Yue Sun, Ying Ma and Qiming Li

J Sci Food Agric, 2023, 103, 4625
DOI: 10.1002/jsfa.12538

Strategically using Yupingfeng polysaccharides to improve the growth performance, antioxidant capacity, liver health, and lipid metabolism of largemouth bass (Micropterus salmoides) under a high-lipid diet

Zhuozhi Ou, Yuhua Yue, Xianjun Feng, Yanming Qiu, Hui Yu and Yingying Yu

Aquaculture Reports, 2024, 39, 102473
DOI: 10.1016/j.aqrep.2024.102473

A review: Mechanism and research progress of the effects of Astragalus polysaccharides on obesity

Anna Wang, Gang Liu, Lin Zheng and Shuangshuang Wang

International Journal of Biological Macromolecules, 2025, 311, 143984
DOI: 10.1016/j.ijbiomac.2025.143984

Lead exposure aggravates glucose metabolism disorders through gut microbiota dysbiosis and intestinal barrier damage in high‐fat diet‐fed mice

Nana Wang, Xue Gao, Yuan Huo, Yuting Li, Fangru Cheng and Zengli Zhang

J Sci Food Agric, 2024, 104, 3057
DOI: 10.1002/jsfa.13197

Astragalus polysaccharide inhibits lipogenesis in HFD-fed mice by suppressing LIPG via upregulation of UDPG

Xuelin Wang, Mengying Li, Fang Yu, Limin Hou, Rui Cao, Lei Zhang, Jianwu Xie, Feng Wang and Junrong Huang

Adv Compos Hybrid Mater, 2024, 7
DOI: 10.1007/s42114-024-01046-7

Pharmacology of bioactive compounds from plant extracts for improving non-alcoholic fatty liver disease through endoplasmic reticulum stress modulation: A comprehensive review

Liying Huang, Liping Tan, Zhuo Lv, Wenhui Chen and Junzi Wu

Heliyon, 2024, 10, e25053
DOI: 10.1016/j.heliyon.2024.e25053

Astragalus Mongholicus Polysaccharides Alleviate Kidney Injury in Rats with Type 2 Diabetes Through Modulation of Oxidation, Inflammation, and Gut Microbiota

Guoquan Xu, Haisheng Yuan, Jingran Liu, Xianjue Wang, Li Ma, Yuzhen Wang and Guicheng Dong

IJMS, 2025, 26, 1470
DOI: 10.3390/ijms26041470

Hepatobiliary and pancreatic: Multi‐donor fecal microbiota transplantation attenuated high‐fat diet‐induced hepatic steatosis in mice by remodeling the gut microbiota

Diwen Shou, Qingling Luo, Wenjuan Tang, Chuangyu Cao, Hongli Huang, Huiting Chen and Yongjian Zhou

J of Gastro and Hepatol, 2023, 38, 2195
DOI: 10.1111/jgh.16359

Protective Mechanism of Auricularia auricula Polysaccharides Against Acute Alcoholic Liver Injury Is Related to Different Consumption Doses

Haili Niu, Fangjia Zhao, Zeyu Hu, Qi Wang, Yuan Li, Ivan Kurtovic, Yahong Yuan and Tianli Yue

eFood, 2026, 7
DOI: 10.1002/efd2.70125

Effects of different addition levels of CHM-JM113 on growth performance, antioxidant capacity, organ index, and intestinal health of AA broilers

Guanhua Fu, Mengyu Zhang, Yuanyuan Huang, Runyu Han, Kaixuan Qi, Lidong Yin, Dongchen Zhao, Yueyan Huang, Tenghe Ma and Lihong Wang

Front. Vet. Sci., 2024, 11
DOI: 10.3389/fvets.2024.1388173

Astragalus polysaccharide alleviates alcoholic-induced hepatic fibrosis by inhibiting polymerase I and transcript release factor and the TLR4/JNK/NF-κB/MyD88 pathway

Xu Sun, Yongqiu Zheng, Yaqing Tian, Qixiang Xu, Shuochuan Liu, Huahua Li, Kunming Cheng, Jianan Yuan, Huaimin Liu and Peng Zhu

Journal of Ethnopharmacology, 2023, 314, 116662
DOI: 10.1016/j.jep.2023.116662

Th17/Treg balance is regulated during the suppression of experimental autoimmune encephalomyelitis treated by Astragalus polysaccharides via the microbiota-gut-brain axis

Jinyun Ma, Xiaojun Liu, Yan Zhao, Qijin Lu, Guiqing Ding, Yuanhua Wang and Xiaodong Cheng

Brain Research Bulletin, 2025, 220, 111171
DOI: 10.1016/j.brainresbull.2024.111171

Astragalus polysaccharide alleviates polycystic ovary syndrome by reducing insulin resistance and oxidative stress and increasing the diversity of gut microbiota

Ruiyun Li, Rui Hu, Yi Huang, Dan Li, Xiaoling Ma and Yuan Yang

Endocrine, 2023, 83, 783
DOI: 10.1007/s12020-023-03553-x

Gut microbiota and its metabolites: A potential approach for traditional Chinese medicine-derived non-starch polysaccharides to delay aging and prevent age-related diseases–A review

Qiling Zhang, Yuling Liu, Ruying Tang, Shasha Kong, Dan Lv, Hui Li, Hongjun Yang and Longfei Lin

Carbohydrate Polymer Technologies and Applications, 2024, 8, 100567
DOI: 10.1016/j.carpta.2024.100567

Rutin ameliorated lipid metabolism dysfunction of diabetic NAFLD via AMPK/SREBP1 pathway

Yadi Liu, Zhongyan Sun, Ruixue Dong, Peiyu Liu, Xi Zhang, Yiran Li, Xiaoshan Lai, Hio-Fai Cheong, Yuwei Wu, Yilin Wang, Hua Zhou, Dingkun Gui and Youhua Xu

Phytomedicine, 2024, 126, 155437
DOI: 10.1016/j.phymed.2024.155437

Investigation of the hypoglycemic mechanism of the ShenQi compound formula through metabonomics and 16S rRNA sequencing

Juan Gao, Xiujuan Zhou, Hong Gao, Guiping Xu, Chunguang Xie and Hongyan Xie

Front. Pharmacol., 2024, 15
DOI: 10.3389/fphar.2024.1349244

Modulatory effects of black jujube melanoidins on gut microbiota and metabolic pathways in high-fat diet-induced obesity

Xi Che, Yifei Zhao, Yuxiao Wang, Xin Sun, Hongxun Tao and Rentang Zhang

Front. Nutr., 2025, 12
DOI: 10.3389/fnut.2025.1580439

Modulating effects of Astragalus polysaccharide on immune disorders via gut microbiota and the TLR4/NF-κB pathway in rats with syndrome of dampness stagnancy due to spleen deficiency

Wenxiao Zhao, Chenchen Duan, Yanli Liu, Guangying Lu, Qin Lyu, Xiumei Liu, Jun Zheng, Xuelian Zhao, Shijun Wang and Haijun Zhao

J. Zhejiang Univ. Sci. B, 2023, 24, 650
DOI: 10.1631/jzus.B2200491

Silibinin Targeting Heat Shock Protein 90 Represents a Novel Approach to Alleviate Nonalcoholic Fatty Liver Disease by Simultaneously Lowering Hepatic Lipotoxicity and Enhancing Gut Barrier Function

Baofei Yan, Xian Zheng, Xi Chen, Huihui Hao, Shen Shen, Jingwen Yang, Siting Wang, Yuping Sun, Jiaqi Xian, Zhitao Shao and Tingming Fu

ACS Pharmacol. Transl. Sci., 2024, 7, 2110
DOI: 10.1021/acsptsci.4c00185

The roles and potential mechanisms of plant polysaccharides in liver diseases: a review

Xianzhi Wei, Daimin Luo, Haonan Li, Yagang Li, Shizhuo Cen, Min Huang, Xianxing Jiang, Guoping Zhong and Weiwei Zeng

Front. Pharmacol., 2024, 15
DOI: 10.3389/fphar.2024.1400958

Astragalus polysaccharides restore neutrophil functions and gut microbiota homeostasis in dairy cows with subclinical ketosis

Shang Jiang, Li Na, Ke Zhang, Kexin Wang, Zhiyong Li, Yiqi Zhang, Yan Ren, Chao Wang, Xiancheng Feng, Yuchen Yang, Chenxi Xue, Jun Chen, Xiliang Du, Lin Lei, Wenwen Gao, Guowen Liu, Yuxiang Song and Xinwei Li

Journal of Dairy Science, 2025, 108, 12632
DOI: 10.3168/jds.2025-26901

Beneficial effect and mechanism of natural resourced polysaccharides on regulating bone metabolism through intestinal flora: A review

Yun Zhou, Yun Jie Sheng, Cheng Yan Li, Li Zou, Chao Ying Tong, Yang Zhang, Gang Cao and Dan Shou

International Journal of Biological Macromolecules, 2023, 253, 127428
DOI: 10.1016/j.ijbiomac.2023.127428

Ugd Is Involved in the Synthesis of Glycans of Glycoprotein and LPS and Is Important for Cellulose Degradation in Cytophaga hutchinsonii

Wenxia Song, Shaoqi Geng, Qingsheng Qi and Xuemei Lu

Microorganisms, 2025, 13, 395
DOI: 10.3390/microorganisms13020395