Issue 8, 2024

Effects of quercetin on the DNA methylation pattern in tumor therapy: an updated review

Abstract

Quercetin is a unique bioactive flavonoid, and is an excellent antioxidant and has anti-tumor effects by regulating different tumor-related processes like proliferation, apoptosis, invasion, and spread. The latest investigations reveal that quercetin may have the capability to influence DNA methylation modification, one of the primary factors in the development of tumors. Despite the fact that quercetin has significant therapeutic properties, its use as an anti-tumor medicine is constrained by its poor solubility, short half-life, and ineffective tumor targeting. Here, we review the structure and properties of quercetin, its capacity for DNA methylation modification in tumors, and the possibility of nanoscale delivery of quercetin for future tumor treatment.

Graphical abstract: Effects of quercetin on the DNA methylation pattern in tumor therapy: an updated review

Article information

Article type
Review Article
Submitted
11 set 2023
Accepted
09 mar 2024
First published
14 mar 2024

Food Funct., 2024,15, 3897-3907

Effects of quercetin on the DNA methylation pattern in tumor therapy: an updated review

Q. Wang, C. Ma, N. Wang and H. Mao, Food Funct., 2024, 15, 3897 DOI: 10.1039/D3FO03831A

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