Issue 32, 2023

Interactions with amyloid beta peptide and acetylcholinesterase increase alkaline phosphatase activity

Abstract

Multiple studies have shown that the activity of alkaline phosphatase (AP) increases during Alzheimer's disease (AD). In this paper, using UV-Visible spectroscopy, we show that this increase in activity is due to its interaction with key components of AD such as amyloid β peptide and acetylcholinesterase. Activity increase also occurs due to high concentrations of acetylcholine and choline. These conditions are present in AD or could occur due to drugs used for treating AD.

Graphical abstract: Interactions with amyloid beta peptide and acetylcholinesterase increase alkaline phosphatase activity

Supplementary files

Article information

Article type
Communication
Submitted
31 mar 2023
Accepted
28 jul 2023
First published
28 jul 2023

Phys. Chem. Chem. Phys., 2023,25, 21149-21153

Author version available

Interactions with amyloid beta peptide and acetylcholinesterase increase alkaline phosphatase activity

A. Bhide and A. Sen, Phys. Chem. Chem. Phys., 2023, 25, 21149 DOI: 10.1039/D3CP01480K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements