A robust CRISPR–Cas12a biosensor coated with metal–organic framework

Lingjun Sha; Yiwei Han; Minghui Wang; Shuai Wu; Jie Yang; Genxi Li

doi:10.1039/D1TB01126J

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

A robust CRISPR–Cas12a biosensor coated with metal–organic framework†

Lingjun Sha,^a Yiwei Han,^b Minghui Wang,^b Shuai Wu,*^b Jie Yang^b and Genxi Li

*^ab

Author affiliations

* Corresponding authors

^a Center for Molecular Recognition and Biosensing, School of Life Sciences, Shanghai University, Shanghai 200444, P. R. China
E-mail: genxili@nju.edu.cn

^b State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, P. R. China
E-mail: shwu@njmu.edu.cn

Abstract

Metal–organic frameworks (MOFs) are proposed to protect a CRISPR-associated enzyme/RNA complex from harsh environments, while the complex can be quickly released from MOFs with high efficiency. Therefore, the application of CRISPR-powered biosensing can be more feasible.

This article is part of the themed collection: Journal of Materials Chemistry B HOT Papers

Download options Please wait...

Supplementary files

Supplementary information PDF (579K)

Article information

DOI: https://doi.org/10.1039/D1TB01126J
Article type: Communication
Submitted: 19 mai 2021
Accepted: 20 jun 2021
First published: 21 jun 2021

Download Citation

J. Mater. Chem. B, 2021,9, 5451-5455

Permissions

Request permissions

A robust CRISPR–Cas12a biosensor coated with metal–organic framework

L. Sha, Y. Han, M. Wang, S. Wu, J. Yang and G. Li, J. Mater. Chem. B, 2021, 9, 5451 DOI: 10.1039/D1TB01126J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Journal of Materials Chemistry B

A robust CRISPR–Cas12a biosensor coated with metal–organic framework†

Abstract

Supplementary files

Article information

Download Citation

Permissions

A robust CRISPR–Cas12a biosensor coated with metal–organic framework

Social activity

Search articles by author

Spotlight

Advertisements