Issue 45, 2019

Lipid nanoparticles – Metvan: revealing a novel way to deliver a vanadium compound to bone cancer cells

Abstract

Cancer is one of the main causes of mortality worldwide. Common therapy schemes are always based on chemotherapy, radiotherapy and/or surgery. Among chemotherapeutics, vanadium compounds have recently emerged as non-platinum antitumor agents. In this sense, Metvan ([VIVO(Me2phen)2(SO4)]) was identified as one of the most promising vanadium anticancer complexes. In this work, the Metvan compound was encapsulated into well designed and developed nanostructured lipid carriers (NLCs) with the aim of improving its biopharmaceutical profile with regards to bioavailability, degradation, solubility and cell up-take. A quality by design approach was followed to find the optimal nanoparticle formulation for Metvan delivery. Results exhibited that the ideal formulation was obtained by using myristyl myristate as the lipid matrix and Pluronic F128 as the stabilizing agent with a mean nanoparticle size of 230.8 ± 3.1 nm and a mean surface charge of −7.9 ± 0.8 mV. The formulation showed an encapsulation efficiency of approximately 80% with a sustained drug release for more than 60 h. The kinetic release mechanism of Metvan from the nanoparticles fitted the Korsmeyer–Peppas model, indicating the Fickian diffusion of Metvan from the nanoparticles. On the other hand, the results showed that the nanoparticle-Metvan system is more effective to decrease cell viability on human osteosarcoma cells (MG-63) compared to the free drug, suggesting a possible different cell internalization mechanism and intracellular effect.

Graphical abstract: Lipid nanoparticles – Metvan: revealing a novel way to deliver a vanadium compound to bone cancer cells

Supplementary files

Article information

Article type
Paper
Submitted
23 abr 2019
Accepted
04 jul 2019
First published
05 jul 2019

New J. Chem., 2019,43, 17726-17734

Lipid nanoparticles – Metvan: revealing a novel way to deliver a vanadium compound to bone cancer cells

M. L. Cacicedo, M. C. Ruiz, S. Scioli-Montoto, M. E. Ruiz, M. A. Fernández, R. M. Torres-Sanchez, E. J. Baran, G. R. Castro and I. E. León, New J. Chem., 2019, 43, 17726 DOI: 10.1039/C9NJ01634A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements