A microfluidic photoreactor enables 2-methylbenzophenone light-driven reactions with superior performance†
Javier
Mateos, 
a
Alessio
Cherubini-Celli,
a
Tommaso
Carofiglio,
a
Marcella
Bonchio,
a
Nadia
Marino,
a
Xavier
Companyó
*a
and
Luca
Dell’Amico
*a
a
Alessio
Cherubini-Celli,
a
Tommaso
Carofiglio,
a
Marcella
Bonchio,
a
Nadia
Marino,
a
Xavier
Companyó
*a
and
Luca
Dell’Amico
*a
Abstract
Light-driven reactions of 2-methylbenzophenones (2-MBPs) occur with improved yields (up to >98%) and reaction rates (up to 0.240 mmol h−1) by using a tailored microfluidic photoreactor (MFP). For the first time, coumarins were converted into 4-benzylated chromanones in high yields (50–93%) and diastereoselectivity (up to >20 : 1 dr), thus by-passing their photo-dimerisation end-reaction.
- This article is part of the themed collection: 2018 Emerging Investigators
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