Issue 30, 2016

Ultra-small lipid–polymer hybrid nanoparticles for tumor-penetrating drug delivery

Abstract

Lipid–polymer hybrid nanoparticles, consisting of a polymeric core coated by a layer of lipids, are a class of highly scalable, biodegradable nanocarriers that have shown great promise in drug delivery applications. Here, we demonstrate the facile synthesis of ultra-small, sub-25 nm lipid–polymer hybrid nanoparticles using an adapted nanoprecipitation approach and explore their utility for targeted delivery of a model chemotherapeutic. The fabrication process is first optimized to produce a monodisperse population of particles that are stable under physiological conditions. It is shown that these ultra-small hybrid nanoparticles can be functionalized with a targeting ligand on the surface and loaded with drug inside the polymeric matrix. Further, the in vivo fate of the nanoparticles after intravenous injection is characterized by examining the blood circulation and biodistribution. In a final proof-of-concept study, targeted ultra-small hybrid nanoparticles loaded with the cancer drug docetaxel are used to treat a mouse tumor model and demonstrate improved efficacy compared to a clinically available formulation of the drug. The ability to synthesize a significantly smaller version of the established lipid–polymer hybrid platform can ultimately enhance its applicability across a wider range of applications.

Graphical abstract: Ultra-small lipid–polymer hybrid nanoparticles for tumor-penetrating drug delivery

Article information

Article type
Paper
Submitted
20 mai 2016
Accepted
05 jul 2016
First published
06 jul 2016

Nanoscale, 2016,8, 14411-14419

Ultra-small lipid–polymer hybrid nanoparticles for tumor-penetrating drug delivery

D. Dehaini, R. H. Fang, B. T. Luk, Z. Pang, C. J. Hu, A. V. Kroll, C. L. Yu, W. Gao and L. Zhang, Nanoscale, 2016, 8, 14411 DOI: 10.1039/C6NR04091H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements