Issue 34, 2024

Harnessing lanthanides for blue-to-UVB upconversion and its dye-sensitization

Abstract

Narrowband UVB light (λ ∼ 310 nm) is broadly applied in topical phototherapies. However, conventional UVB phototherapies have the risk of overexposing healthy skin to UV toxicity. This paper demonstrates the scientific principles in support of an alternative phototherapy protocol, where the UVB radiation is on-site generated by an organic–inorganic hybrid upconverter with a blue light source. Leveraging the intrinsic non-linear nature of photo-upconversion, the process is mechanistically triggered by the two-photon excitation of Ho3+ and the subsequent resonant energy transfer to nearby Gd3+ ions in the NaYF4 host lattice. A sharp upconverted UVB emission peaking at 310 nm is detected from the Gd3+ 6P7/2 excited state. However, the upconversion output is inherently limited by the parity-forbidden intra-4f10 electronic transitions of Ho3+. To boost the blue-to-UVB upconversion, a perylene derivative (PPA2) with a small Stokes shift is deployed as an organic sensitizer. The sensitization effect is realized through Förster resonant energy transfer from PPA2 to the NaYF4:Ho3+,Gd3+ nanoparticles. Under optimized conditions, UVB upconversion of the hybrid nanomaterials outperforms the unsensitized case by a factor of 27. Such sensitized blue-to-UVB upconversion fundamentally consolidates the concept of blue light-stimulated on-site phototherapy, paving the way towards safer therapies in dermatology.

Graphical abstract: Harnessing lanthanides for blue-to-UVB upconversion and its dye-sensitization

Supplementary files

Article information

Article type
Paper
Submitted
27 mai 2024
Accepted
16 jul 2024
First published
30 jul 2024

J. Mater. Chem. C, 2024,12, 13279-13288

Harnessing lanthanides for blue-to-UVB upconversion and its dye-sensitization

D. Yu, B. Li, A. Zhang, J. Pol, D. Zhang, S. Zhuang and D. Zhou, J. Mater. Chem. C, 2024, 12, 13279 DOI: 10.1039/D4TC02187H

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