Issue 27, 2024

Metal-detection based techniques and their applications in metallobiology

Abstract

Metals are essential for human health and play a crucial role in numerous biological processes and pathways. Gaining a deeper insight into these biological events will facilitate novel strategies for disease prevention, early detection, and personalized treatment. In recent years, there has been significant progress in the development of metal-detection based techniques from single cell metallome and proteome profiling to multiplex imaging, which greatly enhance our comprehension of the intricate roles played by metals in complex biological systems. This perspective summarizes the recent progress in advanced metal-detection based techniques and highlights successful applications in elucidating the roles of metals in biology and medicine. Technologies including machine learning that couple with single-cell analysis such as mass cytometry and their application in metallobiology, cancer biology and immunology are also emphasized. Finally, we provide insights into future prospects and challenges involved in metal-detection based techniques, with the aim of inspiring further methodological advancements and applications that are accessible to chemists, biologists, and clinicians.

Graphical abstract: Metal-detection based techniques and their applications in metallobiology

Article information

Article type
Perspective
Submitted
06 jan 2024
Accepted
05 jun 2024
First published
06 jun 2024
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2024,15, 10264-10280

Metal-detection based techniques and their applications in metallobiology

Y. Zhou, H. Li, E. Tse and H. Sun, Chem. Sci., 2024, 15, 10264 DOI: 10.1039/D4SC00108G

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