Ricardo
Labes, 
§a
Julio C.
Pastre,
*ab
Richard J.
Ingham,
¶a
Claudio
Battilocchio,
||a
Henrique M.
Marçon,
b
Mariana C. F. C. B.
Damião,
b
Duc N.
Tran
**a
and
Steven V.
Ley
*a
§a
Julio C.
Pastre,
*ab
Richard J.
Ingham,
¶a
Claudio
Battilocchio,
||a
Henrique M.
Marçon,
b
Mariana C. F. C. B.
Damião,
b
Duc N.
Tran
**a
and
Steven V.
Ley
*a
Abstract
The rapid multistep synthesis of 2-pyrazolines from aldehydes via [3 + 2] cycloaddition of unstabilised diazo species and mono and di-substituted alkenes is reported. The development encompasses semi-continuous and fully continuous methods, including a fully automated compound library generation. A graphical interface was developed for the automation control, making it more accessible for chemists without coding experience.
- This article is part of the themed collection: In Celebration of Klavs Jensen’s 70th Birthday
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