Volume 252, 2024

Spiers Memorial Lecture: Engineering biocatalysts

Abstract

Enzymes are being engineered to catalyze chemical reactions for many practical applications in chemistry and biotechnology. The approaches used are surveyed in this short review, emphasizing methods for accessing reactivities not expressed by native protein scaffolds. The successful generation of completely de novo enzymes that rival the rates and selectivities of their natural counterparts highlights the potential role that designer enzymes may play in the coming years in research, industry, and medicine. Some challenges that need to be addressed to realize this ambitious dream are considered together with possible solutions.

Graphical abstract: Spiers Memorial Lecture: Engineering biocatalysts

Associated articles

Article information

Article type
Paper
Submitted
26 jun 2024
Accepted
26 jun 2024
First published
24 jul 2024
This article is Open Access
Creative Commons BY license

Faraday Discuss., 2024,252, 9-28

Spiers Memorial Lecture: Engineering biocatalysts

D. Hilvert, Faraday Discuss., 2024, 252, 9 DOI: 10.1039/D4FD00139G

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