Volume 252, 2024

Concluding remarks: biocatalysis

Abstract

Biocatalysis is a rapidly evolving field with increasing impact in organic synthesis, chemical manufacturing and medicine. The Faraday Discussion reflected the current state of biocatalysis, covering the design of de novo enzymatic activities, but especially methods for the improvement of enzymes targeting a broad range of applications (i.e., hydroxylations by P450 monooxygenases, enzymatic deprotection of organic compounds under mild conditions, synthesis of chiral intermediates, plastic degradation, silicone polymer synthesis, and peptide synthesis). Central themes have been how to improve an enzyme using methods of rational design and directed evolution, informed by computer modelling and machine learning, and the incorporation of new catalytic functionalities to create hybrid and artificial enzymes.

Graphical abstract: Concluding remarks: biocatalysis

  • This article is part of the themed collection: Biocatalysis

Associated articles

Article information

Article type
Paper
Submitted
06 jun 2024
Accepted
10 jun 2024
First published
10 jun 2024
This article is Open Access
Creative Commons BY license

Faraday Discuss., 2024,252, 507-515

Concluding remarks: biocatalysis

U. T. Bornscheuer, Faraday Discuss., 2024, 252, 507 DOI: 10.1039/D4FD00127C

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