Live chicken egg embryos as an alternative in vivo tumour model for deep surface enhanced Raman spectroscopy

Samantha M. McCabe; Hannah Gardiner; Calum Mullen; Gregory Q. Wallace; Neil C. Shand; Alexander B. Mullen; Linda Horan; Duncan Graham; Karen Faulds; Marie Boyd

doi:10.1039/D4AN00617H

Live chicken egg embryos as an alternative in vivo tumour model for deep surface enhanced Raman spectroscopy†

Samantha M. McCabe,

^abc Hannah Gardiner,^b Calum Mullen,

^b Gregory Q. Wallace,

^a Neil C. Shand,^c Alexander B. Mullen,^b Linda Horan,^b Duncan Graham,

^a Karen Faulds

*^a and Marie Boyd*^b

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* Corresponding authors

^a Department of Pure and Applied Chemistry, Technology and Innovation Centre, University of Strathclyde, 99 George Street, Glasgow, UK
E-mail: karen.faulds@strath.ac.uk

^b Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow, UK

^c The Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, UK

Abstract

Live chicken egg embryos offer new opportunities for evaluation and continuous monitoring of tumour growth for in vivo studies compared to traditional rodent models. Here, we report the first use of surface enhanced Raman scattering (SERS) mapping and surface enhanced spatially offset Raman scattering (SESORS) for the detection and localisation of targeted gold nanoparticles in live chicken egg embryos bearing a glioblastoma tumour.

This article is part of the themed collection: 150th Anniversary Collection: Raman Spectroscopy and SERS

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Live chicken egg embryos as an alternative in vivo tumour model for deep surface enhanced Raman spectroscopy†

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Live chicken egg embryos as an alternative in vivo tumour model for deep surface enhanced Raman spectroscopy

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