Issue 39, 2023

Green synthesis of metal–organic framework loaded dexamethasone on wood aerogels for enhanced cranial bone regeneration

Abstract

Bone defects have attracted increasing attention in clinical settings. To date, there have been no effective methods to repair defective bones. Balsa wood aerogels are considered as an excellent source of chemicals for chemical modification to facilitate the in situ immobilization of zeolitic imidazolate framework-8. Furthermore, dexamethasone has received considerable attention for bone tissue engineering. In this study, for the first time, a simple but effective one-pot method for developing a novel zeolitic imidazolate framework-8 with different concentrations of dexamethasone was developed. These findings illustrate that the novel scaffold has a significant positive impact on osteogenic differentiation in vitro and repairs defects in vivo, suggesting that it can be used in bone tissue engineering.

Graphical abstract: Green synthesis of metal–organic framework loaded dexamethasone on wood aerogels for enhanced cranial bone regeneration

Article information

Article type
Paper
Submitted
30 jun 2023
Accepted
04 set 2023
First published
21 set 2023

J. Mater. Chem. B, 2023,11, 9496-9508

Green synthesis of metal–organic framework loaded dexamethasone on wood aerogels for enhanced cranial bone regeneration

Z. Chen, R. Wang, S. Su, Y. Hao and F. Zhou, J. Mater. Chem. B, 2023, 11, 9496 DOI: 10.1039/D3TB01484C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements