Issue 24, 2023
From the journal:

Nanoscale Advances

Hybrid AuNPs-3MPS-MTX nanosystem and its evaluation for treating cervical cancer and melanoma

M. J. Hernández-Esparza,ab   Ilaria Fratoddi, ORCID logo b   Sara Cerra, ORCID logo b   K. Juarez-Moreno ORCID logo *c  and  R. Huirache-Acuña ORCID logo *a  

* Corresponding authors

a Facultad de Ingeniería Química, Universidad Michoacana de San Nicolás de Hidalgo, Ciudad Universitaria, Morelia, Mexico
E-mail: rafael.huirache@umich.mx

b Department of Chemistry, University Sapienza of Rome, p. Aldo Moro 5, 00185 Rome, Italy

c Centro de Física Aplicada y Tecnología Avanzada, Universidad Nacional Autónoma de México, Mexico
E-mail: kjuarez@fata.unam.mx

Abstract

This research presents an evaluation of a hybrid material based on gold nanoparticles (AuNPs), stabilized with the thiol 3-mercapto-propanesulfonate (3MPS) and loaded with the methotrexate drug (MTX). The AuNPs-3MPS-MTX nanosystem was tested for the treatment of cervical cancer and melanoma, using the B16-F10 melanoma and HeLa cell lines. The tests performed on cell cultures assessed the efficiency of the studied nanosystem on tumor cells, as well as its toxicology.

Graphical abstract: Hybrid AuNPs-3MPS-MTX nanosystem and its evaluation for treating cervical cancer and melanoma

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Article information

DOI
https://doi.org/10.1039/D3NA00605K
Article type
Paper
Submitted
06 ago 2023
Accepted
16 nov 2023
First published
17 nov 2023
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2023,5, 7077-7085

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Hybrid AuNPs-3MPS-MTX nanosystem and its evaluation for treating cervical cancer and melanoma

M. J. Hernández-Esparza, I. Fratoddi, S. Cerra, K. Juarez-Moreno and R. Huirache-Acuña, Nanoscale Adv., 2023, 5, 7077 DOI: 10.1039/D3NA00605K

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