Issue 23, 2023

Recent advances in nanoantibiotics against multidrug-resistant bacteria

Abstract

Multidrug-resistant (MDR) bacteria-caused infections have been a major threat to human health. The abuse of conventional antibiotics accelerates the generation of MDR bacteria and makes the situation worse. The emergence of nanomaterials holds great promise for solving this tricky problem due to their multiple antibacterial mechanisms, tunable antibacterial spectra, and low probabilities of inducing drug resistance. In this review, we summarize the mechanism of the generation of drug resistance, and introduce the recently developed nanomaterials for dealing with MDR bacteria via various antibacterial mechanisms. Considering that biosafety and mass production are the major bottlenecks hurdling the commercialization of nanoantibiotics, we introduce the related development in these two aspects. We discuss urgent challenges in this field and future perspectives to promote the development and translation of nanoantibiotics as alternatives against MDR pathogens to traditional antibiotics-based approaches.

Graphical abstract: Recent advances in nanoantibiotics against multidrug-resistant bacteria

Article information

Article type
Review Article
Submitted
15 jul 2023
Accepted
05 out 2023
First published
05 out 2023
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2023,5, 6278-6317

Recent advances in nanoantibiotics against multidrug-resistant bacteria

M. Li, Y. Liu, Y. Gong, X. Yan, L. Wang, W. Zheng, H. Ai and Y. Zhao, Nanoscale Adv., 2023, 5, 6278 DOI: 10.1039/D3NA00530E

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