Issue 54, 2022

Bioactive 2-pyridone-containing heterocycle syntheses using multicomponent reactions

Abstract

2-Pyridone-containing heterocycles are considered privileged scaffolds in drug discovery due to their behavior as hydrogen bond donors and/or acceptors and nonpeptidic mimics, and remarkable physicochemical properties such as metabolic stability, solubility in water, and lipophilicity. This review provides a comprehensive overview of multicomponent reactions (MCRs) for the synthesis of 2-pyridone-containing heterocycles. In particular, it covers the articles published from 1999 to date related to anticancer, antibacterial, antifungal, anti-inflammatory, α-glucosidase inhibitor, and cardiotonic activities of 2-pyridone-containing heterocycles obtained exclusively by an MCR. The discussion focuses on bioactivity data, synthetic approaches, plausible reaction mechanisms, and molecular docking simulations to facilitate comparison and underscore the applications of the 2-pyridone motif in drug discovery and medicinal chemistry. We also present our conclusions and outlook for the future.

Graphical abstract: Bioactive 2-pyridone-containing heterocycle syntheses using multicomponent reactions

Article information

Article type
Review Article
Submitted
07 nov 2022
Accepted
30 nov 2022
First published
07 dez 2022
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2022,12, 35158-35176

Bioactive 2-pyridone-containing heterocycle syntheses using multicomponent reactions

D. Hurtado-Rodríguez, A. Salinas-Torres, H. Rojas, D. Becerra and J. Castillo, RSC Adv., 2022, 12, 35158 DOI: 10.1039/D2RA07056A

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements