Issue 15, 2021

Upconversion nanoparticles modified by Cu2S for photothermal therapy along with real-time optical thermometry

Abstract

Highly effective photothermal conversion performance coupled with high resolution temperature detection in real time is urgently needed for photothermal therapy (PTT). Herein, ultra-small Cu2S nanoparticles (NPs) were designed to absorb on the surface of NaScF4: Yb3+/Er3+/Mn2+@NaScF4@SiO2 NPs to form a central-satellite system, in which the Cu2S NPs play the role of providing significant light-to-heat conversion ability and the Er3+ ions in the NaScF4: Yb3+/Er3+/Mn2+ cores act as a thermometric probe based on the fluorescence intensity ratio (FIR) technology operating in the biological windows. A wavelength of 915 nm is used instead of the conventional 980 nm excitation wavelength to eliminate the laser induced overheating effect for the bio-tissues, by which Yb3+ can also be effectively excited. The temperature resolution of the FIR-based optical thermometer is determined to be better than 0.08 K over the biophysical temperature range with a minimal value of 0.06 K at 298 K, perfectly satisfying the requirements of biomedicine. Under the radiation of 915 nm light, the Cu2S NPs exhibit remarkable light-to-heat conversion capacity, which is proved by photothermal ablation testing of E. coli. The results reveal the enormous potential of the present NPs for PTT integrated with real-time temperature sensing with high resolution.

Graphical abstract: Upconversion nanoparticles modified by Cu2S for photothermal therapy along with real-time optical thermometry

Supplementary files

Article information

Article type
Paper
Submitted
26 dez 2020
Accepted
22 mar 2021
First published
23 mar 2021

Nanoscale, 2021,13, 7161-7168

Upconversion nanoparticles modified by Cu2S for photothermal therapy along with real-time optical thermometry

G. Xiang, Q. Xia, X. Liu, Y. Wang, S. Jiang, L. Li, X. Zhou, L. Ma, X. Wang and J. Zhang, Nanoscale, 2021, 13, 7161 DOI: 10.1039/D0NR09115D

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