Issue 24, 2021

Quantifying the effect of PEG architecture on nanoparticle ligand availability using DNA-PAINT

Abstract

The importance of PEG architecture on nanoparticle (NP) functionality is known but still difficult to investigate, especially at a single particle level. Here, we apply DNA Point Accumulation for Imaging in Nanoscale Topography (DNA-PAINT), a super-resolution microscopy (SRM) technique, to study the surface functionality in poly(lactide-co-glycolide)–poly(ethylene glycol) (PLGA–PEG) NPs with different PEG structures. We demonstrated how the length of the PEG spacer can influence the accessibility of surface chemical functionality, highlighting the importance of SRM techniques to support the rational design of functionalized NPs.

Graphical abstract: Quantifying the effect of PEG architecture on nanoparticle ligand availability using DNA-PAINT

Supplementary files

Article information

Article type
Communication
Submitted
20 set 2021
Accepted
01 nov 2021
First published
01 nov 2021
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2021,3, 6876-6881

Quantifying the effect of PEG architecture on nanoparticle ligand availability using DNA-PAINT

T. Andrian, S. Pujals and L. Albertazzi, Nanoscale Adv., 2021, 3, 6876 DOI: 10.1039/D1NA00696G

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