Issue 21, 2021

Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications

Abstract

For decades, self-assembled lipid vesicles have been widely used in clinics as nanoscale delivery systems for various biomedical applications, including treatment of various diseases. Due to their core–shell architecture and versatile nature, they have been successfully used as carriers for the delivery of a wide range of therapeutic cargos, including drugs and nucleic acids, in cancer treatment. Recently, surface-modified polyamine dendrimer-based vesicles, or dendrimersomes, have emerged as promising alternatives to lipid vesicles for various biomedical applications, due to their ease of synthesis, non-immunogenicity, stability in circulation and lower size polydispersity. This mini-review provides an overview of the recent advances resulting from the use of biomimetic hydrophobically-modified polyamine-based dendrimersomes towards biomedical applications, focusing mainly on the two most widely used polyamine dendrimers, namely polyamidoamine (PAMAM) and poly(propylene imine) (PPI) dendrimers.

Graphical abstract: Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications

Article information

Article type
Minireview
Submitted
02 jul 2021
Accepted
30 ago 2021
First published
01 set 2021
This article is Open Access
Creative Commons BY license

Nanoscale Adv., 2021,3, 6007-6026

Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications

P. Laskar and C. Dufès, Nanoscale Adv., 2021, 3, 6007 DOI: 10.1039/D1NA00536G

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