Issue 50, 2018

A microfluidic photoreactor enables 2-methylbenzophenone light-driven reactions with superior performance

Abstract

Light-driven reactions of 2-methylbenzophenones (2-MBPs) occur with improved yields (up to >98%) and reaction rates (up to 0.240 mmol h−1) by using a tailored microfluidic photoreactor (MFP). For the first time, coumarins were converted into 4-benzylated chromanones in high yields (50–93%) and diastereoselectivity (up to >20 : 1 dr), thus by-passing their photo-dimerisation end-reaction.

Graphical abstract: A microfluidic photoreactor enables 2-methylbenzophenone light-driven reactions with superior performance

Supplementary files

Article information

Article type
Communication
Submitted
16 fev 2018
Accepted
20 mar 2018
First published
21 mar 2018

Chem. Commun., 2018,54, 6820-6823

A microfluidic photoreactor enables 2-methylbenzophenone light-driven reactions with superior performance

J. Mateos, A. Cherubini-Celli, T. Carofiglio, M. Bonchio, N. Marino, X. Companyó and L. Dell’Amico, Chem. Commun., 2018, 54, 6820 DOI: 10.1039/C8CC01373J

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