A chiral aluminum solvating agent (CASA) for 1H NMR chiral analysis of alcohols at low temperature

Min-Seob Seo; Sumin Jang; Hyunwoo Kim

doi:10.1039/C8CC00574E

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A chiral aluminum solvating agent (CASA) for ¹H NMR chiral analysis of alcohols at low temperature†

Min-Seob Seo,^a Sumin Jang^a and Hyunwoo Kim

*^a

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* Corresponding authors

^a Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea
E-mail: hwkim@kaist.edu

Abstract

A chiral aluminum solvating agent (CASA) was demonstrated to be a general and efficient reagent for ¹H NMR chiral analysis of alcohols. The sodium salt of the CASA (CASA-Na) showed a complete baseline peak separation of the hydroxyl group for various chiral alcohols including primary, secondary, and tertiary alcohols with alkyl and aryl substituents in CD₃CN. Due to the weak intermolecular interaction, ¹H NMR measurement at low temperature (−40 to 10 °C) was required.

This article is part of the themed collections: Celebrating the 75th Anniversary of the Korean Chemical Society (KCS) and 2018 Emerging Investigators

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Article information

DOI: https://doi.org/10.1039/C8CC00574E
Article type: Communication
Submitted: 23 jan 2018
Accepted: 05 mar 2018
First published: 06 mar 2018

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Chem. Commun., 2018,54, 6804-6807

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A chiral aluminum solvating agent (CASA) for ¹H NMR chiral analysis of alcohols at low temperature

M. Seo, S. Jang and H. Kim, Chem. Commun., 2018, 54, 6804 DOI: 10.1039/C8CC00574E

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