Issue 8, 2018

Total synthesis of conosilane A via a site-selective C–H functionalization strategy

Abstract

The first total synthesis of conosilane A, a densely oxygenated nonisoprenoid sesquiterpene, has been achieved through stereoselective intramolecular radical cyclization and double utilization of site-selective C–H functionalization as key steps, thus simplifying the synthetic endeavors in natural product synthesis.

Graphical abstract: Total synthesis of conosilane A via a site-selective C–H functionalization strategy

Supplementary files

Article information

Article type
Communication
Submitted
06 dez 2017
Accepted
27 dez 2017
First published
02 jan 2018

Chem. Commun., 2018,54, 912-915

Total synthesis of conosilane A via a site-selective C–H functionalization strategy

Z. Yuan, X. Hu, H. Zhang, L. Liu, P. Chen, M. He, X. Xie, X. Wang and X. She, Chem. Commun., 2018, 54, 912 DOI: 10.1039/C7CC09367E

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