A facile approach for the trifluoromethylthiolation of methylenecyclopropanes

Abstract

A facile approach for the trifluoromethylthiolation of methylenecyclopropanes (MCPs) has been developed by using AgSCF₃/Na₂S₂O₈ as a trifluoromethylthiolation source (SCF₃) to give trifluoromethylthiolated 1,2-dihydro-naphthalene derivatives in moderate to good yields, and the reaction has been proven to go through a radical-type pathway. The products can easily be aromatized upon oxidation, offering a new method for the construction of trifluoromethylthiolated naphthalenes.