Issue 62, 2016

Cu(ii)-catalyzed C6-selective C–H thiolation of 2-pyridones using air as the oxidant

Abstract

The Cu(II)-catalyzed and chelate-directed C6-selective C–H thiolation of 2-pyridones with disulfides was developed to provide aryl and alkyl thioethers. This transformation uses a catalytic amount of Cu(OAc)2 and molecular oxygen in air as an oxidant, no cocatalysts or metallic oxidants are required. The reaction accommodated both electronic and steric factors at the C3–C5 positions of 2-pyridones, which is efficient for the C6 thiolation of a broad range of 2-pyridones with up to 93% yield.

Graphical abstract: Cu(ii)-catalyzed C6-selective C–H thiolation of 2-pyridones using air as the oxidant

Supplementary files

Article information

Article type
Paper
Submitted
18 fev 2016
Accepted
08 jun 2016
First published
10 jun 2016

RSC Adv., 2016,6, 57441-57445

Cu(II)-catalyzed C6-selective C–H thiolation of 2-pyridones using air as the oxidant

P. Peng, J. Wang, C. Li, W. Zhu, H. Jiang and H. Liu, RSC Adv., 2016, 6, 57441 DOI: 10.1039/C6RA04388G

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