Issue 1, 2015
From the journal:

Biomaterials Science

MMP9-sensitive polymers mediate environmentally-responsive bivalirudin release and thrombin inhibition†

D. S. Chu,‡a   D. L. Sellers,‡b   M. J. Bocek,a   A. E. Fischedick,b   P. J. Horner*b  and  S. H. Pun*a  

* Corresponding authors

a Department of Bioengineering and Molecular Engineering and Sciences Institute, University of Washington, Seattle, WA 98195, USA
E-mail: spun@u.washington.edu
Fax: (+)1-206-685-3488

b Department of Neurological Surgery and Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195, USA
E-mail: phorner@u.washington.edu

Abstract

MMP9-responsive bivalirudin-HPMA copolymers were synthesized for direct, local administration in rat spinal cord contusion injury models. Polymer-conjugated bivalirudin peptides maintained activity while demonstrating enzyme-mediated release upon MMP9 exposure and prolonged release from hyaluronic acid/methylcellulose (HAMC) hydrogels compared to free bivalirudin peptide. Localized administration of bivalirudin copolymers in vivo at the site of rat spinal cord injury decreased cellular proliferation and astrogliosis, suggesting the bivalirudin copolymer and HAMC hydrogel system are a promising therapeutic intervention for reducing immediate inflammatory responses and long term scarring.

Graphical abstract: MMP9-sensitive polymers mediate environmentally-responsive bivalirudin release and thrombin inhibition

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Article information

DOI
https://doi.org/10.1039/C4BM00259H
Article type
Communication
Submitted
24 jul 2014
Accepted
22 ago 2014
First published
08 set 2014

Biomater. Sci., 2015,3, 41-45

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MMP9-sensitive polymers mediate environmentally-responsive bivalirudin release and thrombin inhibition

D. S. Chu, D. L. Sellers, M. J. Bocek, A. E. Fischedick, P. J. Horner and S. H. Pun, Biomater. Sci., 2015, 3, 41 DOI: 10.1039/C4BM00259H

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