Issue 41, 2013
From the journal:

RSC Advances

Copper-catalysed amidation of 2-chloro-pyridines†

Lionel Nicolas,a   Patrick Angibaud,b   Ian Stansfield,b   Lieven Meerpoel,c   Sébastien Reymond*a  and  Janine Cossy*a  

* Corresponding authors

a Laboratoire de Chimie Organique, ESPCI ParisTech, UMR CNRS 7084, 10, rue Vauquelin, Paris Cedex 05, France
E-mail: janine.cossy@espci.fr, sebastien.reymond@espci.fr
Fax: (+33)140794660
Tel: (+33)140794659

b Janssen Research & Development, a division of Janssen-Cilag, BP615- Chaussée du Vexin, Val de Reuil, France

c Janssen Research & Development, a division of Janssen Pharmaceutica N.V. Turnhoutsweg 30, Beerse, Belgium

Abstract

The simple and inexpensive N,N-dimethylcyclohexane-1,2-diamine/CuI catalytic system provides a versatile, easy and efficient access to an array of N-(2-pyridin-2-yl)-amides from 2-chloro-pyridine derivatives.

Graphical abstract: Copper-catalysed amidation of 2-chloro-pyridines

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Article information

DOI
https://doi.org/10.1039/C3RA43368D
Article type
Communication
Submitted
12 jun 2013
Accepted
17 jul 2013
First published
19 jul 2013

RSC Adv., 2013,3, 18787-18790

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Copper-catalysed amidation of 2-chloro-pyridines

L. Nicolas, P. Angibaud, I. Stansfield, L. Meerpoel, S. Reymond and J. Cossy, RSC Adv., 2013, 3, 18787 DOI: 10.1039/C3RA43368D

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