Issue 41, 2013

Dual protection of amino functions involving Boc

Abstract

Protecting groups play a pivotal role in the synthesis of multifunctional targets and as amino functions often occur in this context, issues related to their protection become prominent. Primary amines are unique because they can accommodate two such groups. This review highlights various aspects related to the synthesis, properties and applications of products containing one or two Boc-groups resulting from dual protection of amines and amides. Attention is directed towards cases of facilitated cleavage due to mutual interaction between two protecting groups on the same nitrogen.

Graphical abstract: Dual protection of amino functions involving Boc

Article information

Article type
Review Article
Submitted
13 jun 2013
Accepted
16 jul 2013
First published
17 jul 2013
This article is Open Access
Creative Commons BY license

RSC Adv., 2013,3, 18691-18697

Dual protection of amino functions involving Boc

U. Ragnarsson and L. Grehn, RSC Adv., 2013, 3, 18691 DOI: 10.1039/C3RA42956C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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