Issue 32, 2011

Sortase A-catalyzed peptidecyclization for the synthesis of macrocyclic peptides and glycopeptides

Abstract

A chemoenzymatic method was developed for the synthesis of macrocyclic peptides and glycopeptides. Sortase A was found to mediate either head to tail cyclization or oligomerization and then head to tail cyclization of peptides and glycopeptides, depending on the peptide length, to produce 15-mer or higher cyclic peptides and glycopeptides.

Graphical abstract: Sortase A-catalyzed peptide cyclization for the synthesis of macrocyclic peptides and glycopeptides

Supplementary files

Article information

Article type
Communication
Submitted
04 jun 2011
Accepted
20 jun 2011
First published
08 jul 2011

Chem. Commun., 2011,47, 9218-9220

Sortase A-catalyzed peptide cyclization for the synthesis of macrocyclic peptides and glycopeptides

Z. Wu, X. Guo and Z. Guo, Chem. Commun., 2011, 47, 9218 DOI: 10.1039/C1CC13322E

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