Issue 33, 2011

Targeted pH-dependent fluorescent activity-based cathepsin probes

Abstract

Bifunctional, pH-activatable BODIPY dyes were developed and incorporated in mannose cluster-containing activity-based probes for cysteine proteases. Mannose receptor-dependent uptake of the probes in dendritic cells, followed by trafficking to acidic cellular compartments resulted in fluorescence as seen by live-cell imaging, and subsequent cathepsin inhibition.

Graphical abstract: Targeted pH-dependent fluorescent activity-based cathepsin probes

Supplementary files

Article information

Article type
Communication
Submitted
19 mai 2011
Accepted
29 jun 2011
First published
18 jul 2011

Chem. Commun., 2011,47, 9363-9365

Targeted pH-dependent fluorescent activity-based cathepsin probes

S. Hoogendoorn, K. L. Habets, S. Passemard, J. Kuiper, G. A. van der Marel, B. I. Florea and H. S. Overkleeft, Chem. Commun., 2011, 47, 9363 DOI: 10.1039/C1CC12947C

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