Issue 17, 2010

Transition metal-catalyzed addition reactions of arylboronic acids with alkyl 2-formylbenzoates: efficient access to chiral 3-substituted phthalides

Abstract

Transition metal-catalyzed addition of arylboronic acids to 2-formylbenzoates afforded 3-substituted phthalides. By using SPINOL-based phosphites as ligands, a Rh(I)-catalyzed asymmetric version of such an addition reaction was achieved.

Graphical abstract: Transition metal-catalyzed addition reactions of arylboronic acids with alkyl 2-formylbenzoates: efficient access to chiral 3-substituted phthalides

Supplementary files

Article information

Article type
Communication
Submitted
18 jan 2010
Accepted
18 fev 2010
First published
25 mar 2010

Chem. Commun., 2010,46, 3010-3012

Transition metal-catalyzed addition reactions of arylboronic acids with alkyl 2-formylbenzoates: efficient access to chiral 3-substituted phthalides

C. Xing, Y. Liao, P. He and Q. Hu, Chem. Commun., 2010, 46, 3010 DOI: 10.1039/C001104E

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