Issue 1, 2010
From the journal:

Chemical Communications

Highly enantioselective hydrogenation of α-aryl-β-substituted acrylic acids catalyzed by Ir-SpinPHOX†‡

Yi Zhang,ab   Zhaobin Han,b   Fuying Li,a   Kuiling Ding*b  and  Ao Zhang*a  

* Corresponding authors

a Synthetic Organic & Medicinal Chemistry Laboratory, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, P.R. China
E-mail: aozhang@mail.shcnc.ac.cn
Fax: (+86) 21 50806035

b State Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, P.R. China
E-mail: kding@mail.sioc.ac.cn
Fax: (+86) 21 64166128

Abstract

The enantioselective hydrogenation of a series of challenging substrates, α-aryl-β-substituted acrylic acids, was realized with high efficiency and enantioselectivity (up to 96%) under the catalysis of Ir(I) complex of Spiro-based P,N ligand, SpinPHOX.

Graphical abstract: Highly enantioselective hydrogenation of α-aryl-β-substituted acrylic acids catalyzed by Ir-SpinPHOX

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Article information

DOI
https://doi.org/10.1039/B919902K
Article type
Communication
Submitted
24 set 2009
Accepted
11 nov 2009
First published
24 nov 2009

Chem. Commun., 2010,46, 156-158

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Highly enantioselective hydrogenation of α-aryl-β-substituted acrylic acids catalyzed by Ir-SpinPHOX

Y. Zhang, Z. Han, F. Li, K. Ding and A. Zhang, Chem. Commun., 2010, 46, 156 DOI: 10.1039/B919902K

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