Issue 20, 2023

Recent progress in quantitative technologies for the analysis of cancer-related exosome proteins

Abstract

Exosomes are a kind of extracellular vesicles, which play a significant role in intercellular communication and molecular exchange. Cancer-derived exosomes are potential and ideal biomarkers for the early diagnosis and treatment monitoring of cancers because of their abundant biological information and contribution to the interaction between cancer cells and the tumor microenvironment. However, there are a number of drawbacks, such as low sensitivity and tedious steps, in conventional detection techniques. Furthermore, exosome quantification is not enough to accurately distinguish cancer patients from healthy individuals. Therefore, developing efficient, accurate, and inexpensive exosome surface protein analysis techniques is necessary and critical. In recent years, a considerable number of researchers have presented novel detection strategies in this field. This review summarizes the recent progress in quantitative technologies for the analysis of cancer-related exosome proteins, mainly including the detection methods based on aptamers, nanomaterials, and antibodies, discusses a roadmap for future developments, and aims to offer an innovative perspective of exosome research.

Graphical abstract: Recent progress in quantitative technologies for the analysis of cancer-related exosome proteins

Article information

Article type
Critical Review
Submitted
19 jul 2023
Accepted
15 ago 2023
First published
05 set 2023

Analyst, 2023,148, 4954-4966

Recent progress in quantitative technologies for the analysis of cancer-related exosome proteins

Z. Ma, H. Xu and B. Ye, Analyst, 2023, 148, 4954 DOI: 10.1039/D3AN01228J

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