Issue 45, 2021

Porous polycaprolactone and polycarbonate poly(urethane urea)s via emulsion templating: structures, properties, cell growth

Abstract

PolyHIPEs, macroporous polymers templated within high internal phase emulsions (HIPEs), emulsions with over 74% internal phase, are almost always crosslinked to prevent collapse during drying. Here, elastomeric poly(urethane urea) (PUU) polyHIPEs with highly interconnected open-cell structures were synthesized in water-in-oil (w/o) HIPEs. The urethane reactions between a diisocyanate and an oligomeric polyol (a poly(ε-caprolactone) (PCL) diol, a PCL triol, or an aliphatic polycarbonate (PC) diol) occurred in the external phase, while the water-diisocyanate urea reactions occurred at the oil–water interface. The resulting linear macromolecular structures produced unusually soluble polyHIPEs whose thermal transitions and mechanical properties could be fine-tuned through the polyol macromolecular structure and molecular weight and through the urea content (the hydroxyl to isocyanate ratio). The polyHIPEs underwent almost complete degradation in 3 M NaOH, with the PCL-based PUUs undergoing a significantly more rapid degradation. Cells growing in the polyHIPEs adhered to the walls, spread, and penetrated into the porous structures. This work demonstrates that elastomeric, degradable polyHIPEs with potential for tissue engineering applications can be synthesized through the emulsion templating of PUUs with linear macromolecular structures.

Graphical abstract: Porous polycaprolactone and polycarbonate poly(urethane urea)s via emulsion templating: structures, properties, cell growth

Supplementary files

Article information

Article type
Paper
Submitted
15 ago 2021
Accepted
25 out 2021
First published
01 nov 2021

Polym. Chem., 2021,12, 6569-6581

Porous polycaprolactone and polycarbonate poly(urethane urea)s via emulsion templating: structures, properties, cell growth

K. Kapilov-Buchman, T. Bialystocki, D. Niezni, L. Perry, S. Levenberg and M. S. Silverstein, Polym. Chem., 2021, 12, 6569 DOI: 10.1039/D1PY01106E

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