Diethoxyethyl-L-proline (DEP) has been introduced as a new TDG for Pd-catalyzed ortho-arylation of arylamines and aromatic amino acids such as benzylamine, phenethylamine, phenylglycine, and phenylalanine.
The Cu-catalyzed C–H thiolation reaction of aromatic aldehydes has been developed via a transient directing group strategy.
The site-selective cross-dehydrogenative coupling (CDC) of aromatic aldehydes and arenes enabled by heterogeneous glucose-based melanoidin-supported Pd single-atoms/clusters cocatalysts was reported.
Pd-catalyzed ortho-C(sp3)–H arylation of aromatic aldehydes using 2-amino-N-methyl-acetamide as a simple, efficient and commercially available L,L-type transient directing group (TDG) is reported.
Quinoline derivatives are widely found in pharmaceuticals, agrochemicals, and functional materials, and the development of efficient synthetic methods for these compounds has attracted considerable attention.