This review summarizes the synthesis and reactivity of N-aminopyridinium salts, discusses applications in organic synthesis, and highlights the potential for these reagents to enable novel synthetic disconnections and innovations.
A method for the construction of 2-fluoropyrazolo[1,5-a]pyridines through base-promoted [3+2] cycloaddition of N-aminopyridinium salts with gem-difluorostyrenes has been established.
Unsymmetrical vicinal diamines have been achieved via the photoredox-catalyzed difunctionalization of alkenes by using N-aminopyridinium salts and nitriles as the amination reagents, respectively.
This review highlights recent advances in visible-light-driven photochemical multicomponent Minisci reactions. It focuses on their scope, limitations, and reaction mechanisms, offering a comprehensive overview of developments in this area.
A visible-light-enabled catalyst-free [3 + 2] cycloaddition/N–N bond cleavage/intramolecular C–N bond formation cascade process to access 2,3-difunctionalized pyridines was developed.