The electrochemical intramolecular cyclization of ketimines via N–H/N–H dehydrogenation coupling has been established for the construction of 1H-indazole scaffolds.
Indazoles as privileged scaffolds; synthetic strategies; clinical trial compounds; biological activities: anti-tubercular, antifungal, antibacterial, antileishmanial, anti-Parkinson's, anti-inflammatory, antidiabetic, and anticancer.
A highly effective method for synthesizing N-arylhydrazones by means of light-promoted C–N coupling of (hetero)aryl halides with benzophenone hydrazone with catalysis by a Ni(II)–aryl halide complex was reported.
The synthesis of chalcogenated pyrazole-fused isocoumarins and ninhydrin-based hydrazones was accomplished using the same starting materials by changing the solvent and temperature of the reactions.
Herein, we report a t-BuONa-promoted method for the site-selective silylation of 2H-indazoles.