The electrochemical intramolecular cyclization of ketimines via N–H/N–H dehydrogenation coupling has been established for the construction of 1H-indazole scaffolds.
Indazoles as privileged scaffolds; synthetic strategies; clinical trial compounds; biological activities: anti-tubercular, antifungal, antibacterial, antileishmanial, anti-Parkinson's, anti-inflammatory, antidiabetic, and anticancer.
On the basis of available ethynyl vinyl ketones and arylhydrazines, the authors have developed the two-stage synthesis method for styrylpyrazoles possessing fluorescent abilities, as well as the gram-scale synthesis method for fluorescent probes.
A metal- and oxidant-free electrochemical synthesis of valuable indazoles was developed via the dehydrogenative C–N coupling of hydrazones.
A highly effective method for synthesizing N-arylhydrazones by means of light-promoted C–N coupling of (hetero)aryl halides with benzophenone hydrazone with catalysis by a Ni(II)–aryl halide complex was reported.