Microneedle-mediated exosome delivery: a precision strategy in advanced regenerative medicine

Xiang Chen, Qiancheng Gu, Liangle Liu, Anqi Jin, Zhiqiang Jia, Yadie Yu, Lanjie Lei, Qingfei Zhang and Yongliang Li

J. Mater. Chem. B, 2025, 13, 13477
DOI: 10.1039/D5TB01566A

Advances in microneedle technology for skin wound healing: integrating nanomaterials and intelligent drug delivery systems

Yuqing Wang, Yao He, Tao Zhang and Yunfeng Lin

Nanoscale, 2025, 17, 18505
DOI: 10.1039/D5NR01953B

A hydrothermally transformed multifunctional proteinaceous nanoparticle biosealant with intrinsic light-responsive redox cycling for self-sterilizing and accelerated wound healing

Maansi Aggarwal, Purnendu Ghosh, K. P. Mohithraj, Samiran Mondal, Dinesh Kumar Kotnees, Samit Kumar Nandi and Prolay Das

J. Mater. Chem. B, 2026, 14, 2028
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The pursuit of linear dosage in pharmacy: reservoir-based drug delivery systems from macro to micro scale

Arkady S. Abdurashtov, Pavel I. Proshin and Gleb B. Sukhorukov

Expert Opinion on Drug Delivery, 2025, 22, 219
DOI: 10.1080/17425247.2024.2448026

Microneedle for acne treatment: Recent advances in materials and technologies

Han Zheng, Pengxian Wang, Nian Liu, Miao Han, Tianpeng Xu, Shuai Zhao, Yuhe Yang, Xin Zhao and Peng Li

Journal of Materials Science & Technology, 2025, 233, 289
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A Dual‐Layer MOF Microneedle Patch for Self‐Sensitized Mild Photothermal Therapy and Autophagy Regulation

Fang Wang, Weihua Kong, Wangyang Hu, Guizheng Zou, Yin Li and Pei Jiang

Adv Healthcare Materials, 2026
DOI: 10.1002/adhm.202503743

Mesenchymal Stem Cells-Derived Exosomes: Next-Generation Nanomedicines Toward Scarless Wound Healing

Xiaohui Wang, Zhiyuan Xu, Yonggang Lv and Debing Xiang

IJN, 2026, Volume 21, 1
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Smart glucose-ROS responsive CPOD/MGF@GMs hydrogel for mangiferin-mediated diabetic wound healing

Minna Wen, Xinshuo Liu, Yijia Tian, Zexiang Zheng, Shuyun Zhang, Tengfeng Zhuang, Lihua Li and Changren Zhou

Chemical Engineering Journal, 2026, 534, 174749
DOI: 10.1016/j.cej.2026.174749

Modelos cinéticos para evaluar la liberación controlada de fármacos desde exosomas

Saúl Jiménez-Jiménez, Alejandro Canales-Aguirre, Salomón Corder- Sánchez, José Gerardo Mejía-Hernández, David Quintanar-Guerrero and Rafael Villalobos-García

MN, 2025, 19, e69875
DOI: 10.22201/ceiich.24485691e.2026.36.69875

Recent Advances in Hydrogel‐Based Strategies for Promoting Wound Healing

Ling Tu, Xiao Luo, Lingfeng Jiang, Menglin Luo, Wenjun Liu, Xin Xie, Lu Zhao, Ling Li and Maochun Zhang

Journal of Polymer Science, 2026, 64, 461
DOI: 10.1002/pol.20250803

Structural Design Strategies for Advancing Sensing on Wearable Meta-Microneedle Bandages

Tong Wu, Xin Li, Bingbing Gao, Ippei Yagi and Chwee Teck Lim

ACS Sens., 2025, 10, 4785
DOI: 10.1021/acssensors.5c01593

Biorthogonal click-immobilized probiotic membrane vesicles in a dynamic hydrogel for accelerated and scar-minimized wound healing

Siqi Zhang, Menglin Zhou, Man-Yuan Li, Renyu Wang, Chengfei Yang, Liuquan Yang, Jingsi Wang, Xufeng Deng, Jigang Dai and Quanxing Liu

Materials Today Bio, 2026, 38, 103046
DOI: 10.1016/j.mtbio.2026.103046

The comparative review of hydrogel and hydrogel microneedle application for transdermal drug delivery

Yan Zhang, Pengyuan Liu, Shaoyu Zhou, Baochun Li, Bingjie Cai, Jingan Li and Kun Zhang

EPMA Journal, 2026
DOI: 10.1007/s13167-026-00451-w

Gynecologic postoperative anti-adhesion barriers: From biomaterials to barrier development

Abbas Fazel Anvari-Yazdi, Daniel J. MacPhee, Ildiko Badea and Xiongbiao Chen

Biomaterials and Biosystems, 2025, 19, 100115
DOI: 10.1016/j.bbiosy.2025.100115

Microneedle-aided nanotherapeutics delivery and nanosensor intervention in advanced tissue regeneration

Churong Xu, Fei Wu, Zhouyi Duan, Bhavana Rajbanshi, Yuxin Qi, Jiaming Qin, Liming Dai, Chaozong Liu, Tuo Jin, Bingjun Zhang and Xiaoling Zhang

J Nanobiotechnol, 2025, 23
DOI: 10.1186/s12951-025-03383-1

Robust self-pumping medical microneedle arrays by nanofiber-reinforced non-covalent cooperative networks

Zhiping Chen, Zhen Xie, Qin Lu, Lingli Tian, Yu Meng, Yichun Xue, Hongxiang Zhu, Lei Wang and Hui He

Adv Compos Hybrid Mater, 2025, 8
DOI: 10.1007/s42114-025-01453-4

Construction and applications of exosome-microneedle integrated systems

Lijie Zheng, Jiting Sun, Lusheng Wang, Zhixian Ding, Yu Tang, Mike Dai and Heng Tang

International Journal of Pharmaceutics: X, 2025, 10, 100360
DOI: 10.1016/j.ijpx.2025.100360

Smart microneedles empowering programmable and sustained drug delivery

Weishu Zeng, Qihang Ding, Zhe Zhang, Jiaqi Zhao, Xu Ding, Pengfei Gao, Minghan Chi, Kun Qian, Manlin Qi, Zhen Cheng and Lin Wang

Coordination Chemistry Reviews, 2026, 548, 217209
DOI: 10.1016/j.ccr.2025.217209

Core-shell ZIF-67/MoS2 heterojunction microneedle accelerates wound healing via enhanced photothermal nanozyme-like activities

Feng Xiao, Haoqun Yao, Ruiyang Qiu, Wenjie You, Zichao Cai, Xiaoyu Wang, Weikang Hu, Weijun Liu and Zijian Wang

Chemical Engineering Journal, 2025, 526, 171230
DOI: 10.1016/j.cej.2025.171230

MicroRNA-493-5p engineered exosomes delivered via piezoelectric microneedles for epigenetic modulation of macrophages in diabetic wound healing

Tao Chen, Lizhi Ouyang, Bobin Mi, Yishen Sheng, Fawwaz AL-Smadi, Hui Xu, Yaosen Wu, Xiaolei Zhang, Kailiang Zhou, Aimin Wu, Xiangyang Wang, Guohui Liu and Wenqian Zhang

Materials Today Bio, 2026, 37, 102931
DOI: 10.1016/j.mtbio.2026.102931

Adhesive and antibacterial guar gum-based nanocomposite hydrogel for remodeling wound healing microenvironment

Weiwei Zhang, Qin He, Ziming Jin, Yuqin Jiang, Zhiguo Hu and Qingcong Wei

International Journal of Biological Macromolecules, 2025, 291, 139054
DOI: 10.1016/j.ijbiomac.2024.139054

Anchoring of Probiotic-Membrane Vesicles in Hydrogels Facilitates Wound Vascularization

Chen Zhou, Hongfu Cao, Yuxiang Wang, Chong Yao, Yaping Zou, Jingyi Liu, Na Li, Tun Yuan, Jie Liang, Qiguang Wang, Yujiang Fan and Xingdong Zhang

ACS Nano, 2025, 19, 3325
DOI: 10.1021/acsnano.4c11986

Intelligent hydrogel-based dressings for treatment of chronic diabetic wounds

Huan Liu and Li He

World J Diabetes, 2025, 16
DOI: 10.4239/wjd.v16.i5.104937

Stem Cell-Derived Exosomes for Diabetic Wound Healing: Mechanisms, Nano-Delivery Systems, and Translational Perspectives

Sumsuddin Chowdhury, Aman Kumar, Preeti Patel, Balak Das Kurmi, Shweta Jain, Banty Kumar and Ankur Vaidya

JNT, 2026, 7, 1
DOI: 10.3390/jnt7010001

Smart core-shell microneedles for psoriasis therapy: In situ self-assembly of calcium ion-coordinated dexamethasone hydrogel

Xinni He, Wanchen Zhao, Huihui Xu, Hongluo Li, Minglong Chen, Yanping Fu, Shujin Liang, Shuling Li, Tingting Peng, Chao Lu, Xin Pan, Chuanbin Wu and Guilan Quan

Journal of Controlled Release, 2025, 379, 786
DOI: 10.1016/j.jconrel.2025.01.037

Bioinspired 3D‐Printed NIR‐Responsive MXene‐Based Multifunctional Eutectogel Microneedles for Personalized Infected Wound Healing

Huan Liu, Aminov Nail, Decheng Meng, Liran Zhu, Xiaohan Guo, Cong Li, Xiaoqing Ye and Huanjun Li

Adv Healthcare Materials, 2025, 14
DOI: 10.1002/adhm.202501344

3D Printing of Customized Carbon Microneedle Arrays

Ya Ren, Li Zhang, Angxi Zhou, Donglin Ma, Haofan Liu, Run Tian, Siyi Wang, Chunli Yang and Maling Gou

MedComm – Biomaterials and Applications, 2025, 4
DOI: 10.1002/mba2.70011

Hypoxia-preconditioned ADSC exosomes encapsulated in a multifunctional dual-network hydrogel promote the healing and functional regeneration of seawater-immersed wounds

Jie Li, Zishuo Wang, Wenjing Yang, Yongchao Zhou, Tao Fu, Yuhui Zhang, Xuzhou Duan, Dong Liu, Lingtong Kong, Yan Shang, Yuchen Zhang, Xuhui Wang, Runze Gao, Cheng Zhong, Long Chen, Qian Liu, Shuogui Xu, Shuo Fang, Yuntong Zhang and Yang Xie

Chemical Engineering Journal, 2025, 518, 164717
DOI: 10.1016/j.cej.2025.164717

Microneedles for anti-aging skincare: Preparation, properties and applications

Khan Manqoosh Awan, Haojie Yu, Li Wang, Abdul Basit, Basem E. Keshta, Yu Wang, Muhammad Owais Malik and Md Alim Uddin

Materials Today Communications, 2024, 41, 110740
DOI: 10.1016/j.mtcomm.2024.110740

Innovative soft materials in hypertrophic scar prevention and treatment: Current progress and clinical insights

Shan Wang, Yangyang Liu, Huiyi Wang and Lei Zhang

Chemical Engineering Journal, 2025, 526, 170822
DOI: 10.1016/j.cej.2025.170822

The Synergistic Applications of Microneedling and Nanomaterials: Attaining Cutaneous Repair

Guotao Wei, Yihao Yuan, Jiapeng Li, Miaohan Qiu, Ruohan Wang, Zhengtai Mao, Linfei Zuo, Dezhi Zhao and Jiawei Wu

Tissue Engineering Part B: Reviews, 2026
DOI: 10.1177/19373368251412766

3D printing for tissue/organ regeneration in China

Chaofan He, Jiankang He, Chengtie Wu, Changshun Ruan, Qi Gu, Yongqiang Hao, Yang Wu, Shuo Bai, Xiaoxiao Han, Liliang Ouyang, Jun Yin, Hongzhao Zhou, Zhuo Xiong, Maobin Xie, Lei Shao, Jing Nie, Liang Ma, Cijun Shuai, Changchun Zhou, Xin Zhao, Xuetao Shi, Mengfei Yu, Jiayin Fu, Peng Wen, Huixia Xuan, Yuan Pang, Yan’en Wang, Yuan Sun, Ziqi Gao, Abdellah Aazmi, Jingbo Zhang, Tianhong Qiao, Qixiang Yang, Ke Yao, Mao Mao, Jianxin Hao, Pinpin Wang, Jirong Yang, Huawei Qu, Xinhuan Wang, Xin Liu, Shen Ji, Shasha Liu, Jingke Fu, Bingxian Lu, Mohan Wu, Feng Chen, Zihao Zheng, Boqing Zhang, Muyuan Chai, Chaoying Zhang, Mouyuan Sun, Bo Peng, Huayong Yang and Yong He

Bio-des. Manuf., 2025, 8, 169
DOI: 10.1631/bdm.2400309

Silk Fibroin Microneedles Loaded with Lipopolysaccharide-Pretreated Bone Marrow Mesenchymal Stem Cell-Derived Exosomes for Oral Ulcer Treatment

Wenhui Ge, Yijun Gao, Yiyu Zeng, Yi Yu, Xiaoyan Xie and Liangle Liu

ACS Appl. Mater. Interfaces, 2024, 16, 37486
DOI: 10.1021/acsami.4c04804

Recent development in targeted gene silencing and cancer therapy by stimuli responsive multifunctional nanoparticles-based drug delivery system

Manoj Singh, Mayank Raj, Vikas Kumar, Sushil Kumar Upadhayay, Mukesh Yadav, Suraj Pal, Aubakirova Aigul, Abzhaparova Balzhan, Novikov Igor and Anil Kumar Sharma

Discov Appl Sci, 2025, 7
DOI: 10.1007/s42452-025-07455-7

Two sides in one coin: Emerging biomimetic multistage ordered microstructure-based adhesion and microfluidics

Meng Wei, Tong Wu, Baoyang Lin, Qian Zhou and Bingbing Gao

Sensors and Actuators A: Physical, 2025, 388, 116496
DOI: 10.1016/j.sna.2025.116496

Gradient Solvent Replacement‐Mediated Formation of High‐Strength Hydrogel‐Forming Microneedle for Long‐Term Drug Delivery

Hui Li, Fengzhen Meng, Chengwei Hu, Zhiyun Wu, Liuzhi Hao, Caijun Sun, Lijing Fang, Fan Pan, Shaoquan Bian, Huipeng Li, Mingjun Li, Bo Liu and Xiaoli Zhao

Advanced Science, 2025, 12
DOI: 10.1002/advs.202500833

Dissolving Microneedles as In Situ Chemical Reaction Chambers: from Design Strategies to Versatile Biomedical Applications

Yu Tian, Lili Xia, Xinran Song and Yu Chen

Adv Funct Materials, 2025, 35
DOI: 10.1002/adfm.202422274

Advances in Research of Hydrogel Microneedle-Based Delivery Systems for Disease Treatment

Juan Cao, Bo Wu, Ping Yuan, Yeqi Liu and Cheng Hu

Pharmaceutics, 2024, 16, 1571
DOI: 10.3390/pharmaceutics16121571

MXene-Derived Multifunctional Biomaterials: New Opportunities for Wound Healing

Dong Luo, Hui-Qi Zhang, Xin-Yang Xuanyuan, Dan Deng, Zheng-Mao Lu, Wen-Shang Liu and Meng Li

Biomater Res, 2025, 29
DOI: 10.34133/bmr.0143

Breathable core–shell microneedle patches for diabetic wound treatment

Lu Fan, Yu Wang, Li Wang, Xiang Lin, Xiaoju Wang, Luoran Shang, Hongbo Zhang and Yuanjin Zhao

Mater. Futures, 2025, 4, 025402
DOI: 10.1088/2752-5724/adcbc6

Microneedle Patch Delivering Multifunctional Melanin-like Nanoparticles for Vitiligo Remission and Repigmentation

Zhaoting Jiang, Yuqi Zhou, Bo Wang, Chenhui He, Jia Zhang, Qi Wang, Ziwei Deng, Chunying Li and Zhe Jian

ACS Appl. Mater. Interfaces, 2025, 17, 68894
DOI: 10.1021/acsami.5c11865

Microneedle technology: a gateway to transformative healthcare solutions

Neha Bajwa, Vighnesh Devulapalli, Mahendra Pratap Singh, Kumbha Gopi, Sanobar Shariff, Pavan Kumar and Carlos Quispe-Vicuña

the.evi., 2024, 2
DOI: 10.61505/evidence.2024.2.3.57

A core–shell microneedle platform for the spatiotemporal codelivery of dual-agent therapeutics precisely orchestrates diabetic wound healing

Yuhang Zhan, Zhihan Zhang, Zhiyue Zhang, Mengru Lin, Hui Liu, Dilihumaer Abulimiti, Shami Aihemaiti, Yun Kan, Jinhai Tan, Xi Chen and Shengxiang Tao

J Nanobiotechnol, 2026
DOI: 10.1186/s12951-026-04155-1