Characterization of PKCα-rutin interactions and their application as a treatment strategy for pulmonary arterial hypertension by inhibiting ferroptosis

Haixia Che, Jie Yi, Xiaoting Zhao, Hong Yu, Xianyao Wang, Rui Zhang, Xin Li, Jia Fu and Qian Li

Food Funct., 2024, 15, 779
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Self-assembled nanoplatform-mediated co-delivery of brusatol to sensitize sorafenib for hepatocellular carcinoma treatment

Fengrui Liu, Senlin Li, Chengcheng Huang, Zhenfei Bi, Xiao Xiang, Shuqi Zhang, Ruihao Yang and Lu Zheng

RSC Adv., 2025, 15, 11675
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Emulsified isoflurane pretreatment attenuates myocardial ischemia-reperfusion injuries by suppressing toll-like Receptor-4

Zujin Xu, Zhen Li, Shuxian Chen, Yali Zhu, Yanlin Wang, Jia Zhan and Yun Wu

Immunopharmacology and Immunotoxicology, 2024, 46, 751
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Ferroptosis in organ fibrosis: From mechanisms to therapeutic medicines

Weijing Lai, Bo Wang, Rongshuang Huang, Chuyue Zhang, Ping Fu and Liang Ma

Journal of Translational Internal Medicine, 2024, 12, 22
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Targeted Delivery and ROS-Responsive Release of Lutein Nanoassemblies Inhibit Myocardial Ischemia-Reperfusion Injury by Improving Mitochondrial Function

Pilong Shi, Yuetong Sha, Xinran Wang, Tao Yang, Jiawei Wu, Jiajun Zhou, Kai Liu, Xue Guan, Song Wang, Yongsheng Liu, Jingquan Gao, Hongli Sun, Tao Ban and Yonggang Cao

IJN, 2024, Volume 19, 11973
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Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects

Qin Ru, Yusheng Li, Lin Chen, Yuxiang Wu, Junxia Min and Fudi Wang

Sig Transduct Target Ther, 2024, 9
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3-hydroxyanthranilic acid analog mitigates ischemia-reperfusion injury by inhibiting cardiomyocyte ferroptosis through the activation of Nrf2/HO-1/GPX4

Hao-Yuan Yang, Zi-Yan Liu, Zhen-Qiang Xu, Lin-Song Teng, Xie-Huang Sheng, Gang Zhang and Fu-Sheng Zhang

International Immunopharmacology, 2025, 162, 115117
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RGS12 is a target of penehyclidine hydrochloride that enhances oxidative stress and ferroptosis in a model of myocardial ischemia/reperfusion injury by inhibiting the Nrf2 pathway

Congna Zi, Yulei Wei, Ying Zhu and Juan Fan

Int J Mol Med, 2025, 55
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Mechanisms of Vitamins Inhibiting Ferroptosis

Meng Zhang, Xin Chen and Yumei Zhang

Antioxidants, 2024, 13, 1571
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Mechanism of Fucoxanthin on Ferroptosis of Human Erythroleukemia Cells Via the TFR1/SLC7A11/GPX4 Signaling Pathway

Bi Wang, Siyu Wang, Haofei Du, Ziyan Yang, Xiuqiang Zhang, Caisheng Wang and Haomiao Ding

JCMP, 2025, 7, 201
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Targeting Ferroptosis Alleviates Pulmonary Arterial Hypertension, Insights from Transcriptomic and Experimental Analyses

Xiaowan Wang and Qiang Guo

Advanced Biology, 2025
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A review of the application of small organic molecule fluorescent probes in ischemia-reperfusion injury

Xinfeng Zhang, Nazeer Muhammad Nouman, Caixia Yin and Fangjun Huo

Dyes and Pigments, 2025, 233, 112524
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Myricetin inhibits 4 T1 breast tumor growth in mice via induction of Nrf-2/GPX4 pathway-mediated Ferroptosis

Xiaomin Niu, Xuhao Ding, Qing Tong, Xueru Huang, Xiaolan Ma, Ziping Li, Qian Wang and Yi Wang

Toxicology and Applied Pharmacology, 2024, 488, 116990
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Single-Cell WGCNA Combined with Transcriptome Sequencing to Study the Molecular Mechanisms of Inflammation-Related Ferroptosis in Myocardial Ischemia-Reperfusion Injury

Zhuohua Zhang, Yan Liu, Da Huang and Zhaohe Huang

JIR, 2024, Volume 17, 6203
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Sanguinarine attenuates hypoxia/reoxygenation-triggered H9c2 cell injury through activation of the Nrf2/NLRP3 pathway

Bo Qiu, Xin Li and Wenna Wang

J. Clin. Biochem. Nutr., 2025, 77, 37
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Ferroptosis and myocardial ischemia-reperfusion: mechanistic insights and new therapeutic perspectives

Binwei Jin, Zhiming Zhang, Yang Zhang, Minjun Yang, Cheng Wang, Jiayi Xu, Yu Zhu, Yafei Mi, Jianjun Jiang and Zhenzhu Sun

Front. Pharmacol., 2024, 15
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The role and possible mechanism of the ferroptosis-related SLC7A11/GSH/GPX4 pathway in myocardial ischemia-reperfusion injury

Bingxin Chen, Ping Fan, Xue Song and Mingjun Duan

BMC Cardiovasc Disord, 2024, 24
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Potential Targets of Natural Products for Improving Cardiac Ischemic Injury: The Role of Nrf2 Signaling Transduction

Haixia Wang, Juanjuan Han, Gorbachev Dmitrii and Xin-an Zhang

Molecules, 2024, 29, 2005
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Ciprofol Ameliorates Myocardial Ischemia/Reperfusion Injury by Inhibiting Ferroptosis Through Upregulating HIF-1α

Jun Ding, Bi-Ying Wang, Yu-Fan Yang, Ling-Yu Kuai, Jing-jie Wan, Mian Zhang, Hai-Yan Xia, Yao Wang, Zhong Zheng, Xiao-Wen Meng, Ke Peng and Fu-Hai Ji

DDDT, 2024, Volume 18, 6115
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The effect and mechanism of areca nut in ovarian cancer were investigated based on network pharmacology, molecular docking, and in vitro experiments

Shumin Xu, Qinran Zhu, Jian Zhang, Xin Li, Meng Liang and Junpei Sun

Biochemical and Biophysical Research Communications, 2025, 771, 151943
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Naringin attenuates myocardial ischemia-reperfusion injury by promoting mitochondrial translocation of NDUFS1 and suppressing cardiac microvascular endothelial cell ferroptosis

Xue Guan, Zhenyu Yang, Jinming Wang, Wei Lu, Shilin Wang, Mi Yang, Pengbo Sun, Wenfu Hu, Liming Yang and Hong Li

The Journal of Nutritional Biochemistry, 2025, 145, 110019
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Acupuncture attenuates myocardial ischemia/reperfusion injury-induced ferroptosis via the Nrf2/HO-1 pathway

Xiao Li, Yu-xin Sun, Adi Wirawan Tjahjono, Ying Wei, Xiang Li, Qian-hua Zheng, Wen-chuan Qi and Fan-rong Liang

Chin Med, 2025, 20
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Protective effect of norepinephrine, dopamine and N-methyldopamine against chemically-induced oxidative ferroptosis in HT22 neuronal cells: Protein disulfide isomerase as a mechanistic target for protection

Ming-Jie Hou, Qiushi Guo and Bao Ting Zhu

Free Radical Biology and Medicine, 2025, 237, 631
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Marine Natural Products in Inflammation‐Related Diseases: Opportunities and Challenges

Tao Zhang, Zijun Ouyang, Yueran Zhang, Haiyan Sun, Lingdong Kong, Qiang Xu, Jiao Qu and Yang Sun

Medicinal Research Reviews, 2025, 45, 1375
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The interaction between ferroptosis and myocardial ischemia–reperfusion injury: molecular mechanisms and potential therapeutic targets

Tiantian Zhang, Yue Han, Yongcheng Wang, Xiaoyu Wang, Mingchen Zhao, Ziyang Cheng and Shiliang Zhang

Eur J Med Res, 2025, 30
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Shexiang Tongxin Dripping Pills regulates SOD/TNF-α/IL-6 pathway to inhibit inflammation and oxidative stress to improve myocardial ischemia-reperfusion injury in mice

Wanying Du, Chenguang Zhai, Huijie Zhang, Jun Ren, Xiaoyang Chen, Xuejing Sun, Chun Li, Wei Wang and Yijun Chen

Front. Cardiovasc. Med., 2025, 12
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Intervention of natural products targeting novel mechanisms after myocardial infarction

Guangjie Tai, Renhua Liu, Tian Lin, Jiancheng Yang, Xiaoxue Li and Ming Xu

Chinese Journal of Natural Medicines, 2025, 23, 658
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Management of ROS and Regulatory Cell Death in Myocardial Ischemia–Reperfusion Injury

Ge Gong, Wenhui Wan, Xinghu Zhang, Xiangxuan Chen and Jian Yin

Mol Biotechnol, 2025, 67, 1765
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Ferroptosis in Cardiovascular Diseases and Ferroptosis-Related Intervention Approaches

Xianpeng Zhou, Hao Wang, Biao Yan, Xinwen Nie, Qingjie Chen, Xiaosong Yang, Min Lei, Xiying Guo, Changhan Ouyang and Zhanhong Ren

Cardiovasc Drugs Ther, 2024
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Discovering the active components of Rosa davurica Pall on ameliorating acute myocardial ischemia based on spectral relationships, network pharmacology, molecular docking and molecular dynamic.

Ze-Yu Yi, Meng Zhang, Shuo Wang, Si-Yu Liu, Lin-Cheng Bai, Cai-Yan Liu, Hua Han, Zun-Peng Shu and Xiao-Jin Yu

Fitoterapia, 2025, 184, 106648
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PEDF and 34‐mer peptide inhibit cardiac microvascular endothelial cell ferroptosis via Nrf2/HO‐1 signalling in myocardial ischemia‐reperfusion injury

Peng Lu, Yuanpu Qi, Xiangyu Li, Cheng Zhang, Zhipeng Chen, Zihao Shen, Jingtian Liang, Hao Zhang and Yanliang Yuan

J Cellular Molecular Medi, 2024, 28
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Fucoxanthin Inhibits the Proliferation and Metastasis of Human Pharyngeal Squamous Cell Carcinoma by Regulating the PI3K/Akt/mTOR Signaling Pathway

Hao-Fei Du, Jia-Min Jiang, Si-Han Wu, Yan-Fang Shi, Hai-Tian Liu, Zheng-Hao Hua, Cai-Sheng Wang, Guo-Ying Qian and Hao-Miao Ding

Molecules, 2024, 29, 3603
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ETS1 modulates ferroptosis to affect the process of myocardial ischemia-reperfusion injury via PIM3

Ting Li, Xuefeng Xu, Tao Zhou, Xuan Xie, Yutao Peng, Li He, Jin He and Wangsheng Luo

Experimental Cell Research, 2025, 448, 114550
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Longikaurin A induces ferroptosis and inhibits glioblastoma progression through DNA methylation - Mediated GPX4 suppression

Xiangrui Meng, Qingqing Yang, Yisu Gao, Yawei Liu, Fang Chen, Wangsen Cao and Guan Sun

European Journal of Pharmacology, 2024, 984, 177061
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Mitochondrial Ferritin Overexpression Attenuates Ferroptosis and Mitochondrial Dysfunction by Reducing VDAC1 to Relieve MI/RI‐Induced Damage

Yong Yuan, Xiuqi Wang, Huaihuan Xu, Lanxiang Liu, Jichun Liu, Songqing Lai and Huang Huang

J Cellular Molecular Medi, 2025, 29
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Gossypol Acetic Acid Alleviates the Ferroptosis of Chondrocytes in Osteoarthritis by Inhibiting GPX4 Methylation

Jingjing Shang, Chenwei Xiong, Wei Jiang, Zhentang Yu, Junjie Zhang, Yi Zhang, Long Han, Kaisong Miao, Changlin Yu, Yong Huang and Xindie Zhou

CMC, 2025, 32, 2422
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Strong protection by bazedoxifene against chemically-induced ferroptotic neuronal death in vitro and in vivo

Xiangyu Hao, Yifan Wang, Ming-Jie Hou, Yong Xiao Yang, Lixi Liao, Tongxiang Chen, Pan Wang, Xiaojun Chen and Bao Ting Zhu

Cell Commun Signal, 2025, 23
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Ferroptosis: A novel therapeutic target for diabetic cardiomyopathy

Gui-Zhi Li, Jia-Yin Liu and Hong Zhou

World J Diabetes, 2025, 16
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Oroxylin A alleviates myocardial ischemia–reperfusion injury by quelling ferroptosis via activating the DUSP10/MAPK‐Nrf2 pathway

Yifeng Jin, Mingyue Tan, Yunfei Yin, Chen Lin, Yongjian Zhao, Jun Zhang, Tingbo Jiang, Hongxia Li and Mingqing He

Phytotherapy Research, 2024, 38, 5290
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Fucoxanthin extraction, characterization, and protective effects against tartrazine-induced oxidative, inflammatory, and histological sperm damage in rats

Faiza I.A. Abdella, Maha Awjan Alreshidi, Tahani Y.A. Alanazi, Hissah Khashman Alshammari, Hessah Difallah A Al-Enazy and Khaled Hamden

Food Bioscience, 2025, 71, 107356
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