The microbiota-gut-brain axis: a potential target in the small-molecule compounds and gene therapeutic strategies for Parkinson’s disease

Fengjuan Jiao, Lincong Zhou and Zaixin Wu

Neurol Sci, 2025, 46, 561
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The investigation of the mechanism underlying variations in oxidative stress tolerance of Lacticaseibacillus paracasei resulting from fermentation methods through endogenous CRISPR-Cas9 editing methodology

Pengyu Wu, Yutian Zhang, Qiantong Shan, Ziyang Wang, Shuang Cheng, Laiyou Wang, Bingbing Liu, Wenhuan Li, Zhenmin Chen, Jiancheng Luo and Yunxiang Liang

Food Microbiology, 2025, 127, 104697
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The Role of the Gastrointestinal Microbiota in Parkinson’s Disease

Maurizio Gabrielli, Lorenzo Zileri Dal Verme, Maria Assunta Zocco, Enrico Celestino Nista, Veronica Ojetti and Antonio Gasbarrini

Biomolecules, 2024, 15, 26
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Breaking the Cycle: Can Vitamin D Bridge the Gap Between Gut Microbiota and Immune Dynamics in Multiple Sclerosis?

Feray Gençer Bingöl, Emine Kocyigit, Elif Çelik, Duygu Ağagündüz and Ferenc Budán

IJMS, 2025, 26, 5464
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Pharmacomicrobiomics: a new field contributing to optimizing drug therapy in Parkinson’s disease

Yi Zhang, Chengjun Mo, Penghui Ai, Xiaoqin He, Qin Xiao and Xiaodong Yang

Gut Microbes, 2025, 17
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Bacterial live therapeutics for human diseases

Elisabet Frutos-Grilo, Yamile Ana, Javier Gonzalez-de Miguel, Marcel Cardona-i-Collado, Irene Rodriguez-Arce and Luis Serrano

Mol Syst Biol, 2024, 20, 1261
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Nutritional and dietary clinical trials for Parkinson's disease: a narrative review

Alexandros Giannakis, Maria Chondrogiorgi, Spiridon Konitsiotis and Christos Sidiropoulos

J Neural Transm, 2025, 132, 519
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A neurotherapeutic approach with Lacticaseibacillus rhamnosus E9 on gut microbiota and intestinal barrier in MPTP-induced mouse model of Parkinson’s disease

Busra Aktas, Belma Aslim and Deniz Ates Ozdemir

Sci Rep, 2024, 14
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Exploring the interaction between the gut microbiota and cyclic adenosine monophosphate-protein kinase A signaling pathway: a potential therapeutic approach for neurodegenerative diseases

Fengcheng Deng, Dan Yang, Lingxi Qing, Yifei Chen, Jilian Zou, Meiling Jia, Qian Wang, Runda Jiang and Lihua Huang

Neural Regeneration Research, 2025, 20, 3095
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The Gut–Brain Axis and Probiotics in Beverages and Liquid Preparations: A PRISMA Systematic Review on Cognitive Function Enhancement

Alfonso Filippone, Umberto Barbieri, Maria Rosaria Corbo, Milena Sinigaglia and Antonio Bevilacqua

Beverages, 2025, 11, 85
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The Gut Microbiota in Parkinson Disease: Interactions with Drugs and Potential for Therapeutic Applications

Elisa Menozzi and Anthony H. V. Schapira

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Comparative efficacy of non-pharmacological interventions for Parkinson’s disease with constipation: a systematic review and network meta-analysis

Peiying Zhang, Xiaojuan Su, Xuan Han, Dingmeng Zhao, Jinyan Wang, Yanyi Yang and Hejiang Ye

Front. Neurol., 2025, 16
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The Gut Microbiome as a Catalyst and Emerging Therapeutic Target for Parkinson’s Disease: A Comprehensive Update

Rebecca Kerstens and Paul Joyce

Biomedicines, 2024, 12, 1738
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Management of Gastrointestinal Symptoms in Parkinson’s Disease

Han-Lin Chiang and Chin-Hsien Lin

J Cent Nerv Syst Dis, 2025, 17
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Can microbiota gut-brain axis reverse neurodegenerative disorders in human?

Xingxing Yuan, Serge Yannick Ouedraogo, Modou Lamin Jammeh, Lucette Simbiliyabo, John Nute Jabang, Mariam Jaw, Alansana Darboe, Yurong Tan and Ousman Bajinka

Ageing Research Reviews, 2025, 104, 102664
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Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Jian Sheng Loh, Wen Qi Mak, Li Kar Stella Tan, Chu Xin Ng, Hong Hao Chan, Shiau Hueh Yeow, Jhi Biau Foo, Yong Sze Ong, Chee Wun How and Kooi Yeong Khaw

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The role of microbiota dysbiosis in Parkinson’s disease: Pathophysiology and therapeutic opportunities

Shabnam Santos, Ivonne Salinas, Nicolás Almeida and Andrés Caicedo

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Advice to People with Parkinson’s in My Clinic: Probiotics and Prebiotics

Jia Wei Hor, Tzi Shin Toh, Shen-Yang Lim and Ai Huey Tan

Journal of Parkinson’s Disease, 2024, 14, 1507
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The Role of Microbial Metabolites in the Progression of Neurodegenerative Diseases—Therapeutic Approaches: A Comprehensive Review

Jorge Missiego-Beltrán and Ana Isabel Beltrán-Velasco

IJMS, 2024, 25, 10041
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Gut microbiota and Parkinson’s disease

Lin Wang, Ying Cui, Bingyu Han, Yitong Du, Kenish Sirajbhai Salewala, Shiya Wang, Wenlu Zhao, Hongxin Zhang, Sichen Wang, Xinran Xu, Jianpeng Ma, Yan Zhu and Houzhen Tuo

Chinese Medical Journal, 2025, 138, 289
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Probiotics as Potential Treatments for Neurodegenerative Diseases: a Review of the Evidence from in vivo to Clinical Trial

Jin Hee Kim, Yujin Choi, Seungmin Lee and Myung Sook Oh

Biomol Ther (Seoul), 2025, 33, 54
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The Effect of Probiotic Lactic Acid Bacteria on the Symptoms of Mental Disorders

V. A. Novikova, K. D. Bondarenko, A. E. Sazonov and A. S. Rozanov

Nanotechnol Russia, 2024, 19, 645
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The Interaction Between Nutraceuticals and Gut Microbiota: a Novel Therapeutic Approach to Prevent and Treatment Parkinson’s Disease

Liyan Yao, Yong Yang, Xiaowei Yang and Mohammad J. Rezaei

Mol Neurobiol, 2024, 61, 9078
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Role of the Intestinal Microbiota in the Molecular Pathogenesis of Atypical Parkinsonian Syndromes

Dominika Przewodowska, Piotr Alster and Natalia Madetko-Alster

IJMS, 2025, 26, 3928
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The Impact of Probiotics on Clinical Symptoms and Peripheral Cytokines Levels in Parkinson’s Disease: Preliminary In Vivo Data

Luca Magistrelli, Elena Contaldi, Annalisa Visciglia, Giovanni Deusebio, Marco Pane and Angela Amoruso

Brain Sciences, 2024, 14, 1147
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Augmenting Cognitive Function in the Elderly with Mild Cognitive Impairment Using Probiotic Lacticaseibacillus rhamnosus CBT-LR5: A 12-Week Randomized, Double-Blind, Parallel-Group Non-Comparative Study

Su-Jin Jung, Kyohee Cho, Eun-Soo Jung, Dooheon Son, Jong-Seon Byun, Song-In Kim, Soo-Wan Chae, Jong-Chul Yang, Seung-Ok Lee and Sanghyun Lim

Nutrients, 2025, 17, 691
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Neuroprotective Potential of Lactic Acid Oligomers Derived from Heat-Killed Lacticaseibacillus paracasei HK-PS23

Yhiya Amen, Chunguang Han, Ahmed Othman, Yanisa Mittraphab, Dongmei Wang, Maki Nagata, Masako Matsumoto, Shusaku Oka, Jun Takehara, Chien-Chen Wu and Kuniyoshi Shimizu

Rev. Bras. Farmacogn., 2025, 35, 830
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Randomized study of Lacticaseibacillus fermented milk in Indonesian elderly houses: Impact on gut microbiota and gut environment

I Nengah Sujaya, Mariyatun Mariyatun, Pratama Nur Hasan, Nancy Eka Putri Manurung, Putrika Citta Pramesi, Mohammad Juffrie, Tyas Utami, Muhammad Nur Cahyanto, Shuta Yamamoto, Takuya Takahashi, Takashi Asahara, Takuya Akiyama and Endang Sutriswati Rahayu

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Thinking outside the brain: Gut microbiome influence on innate immunity within neurodegenerative disease

Andrea R. Merchak, MacKenzie L. Bolen, Malú Gámez Tansey and Kelly B. Menees

Neurotherapeutics, 2024, 21, e00476
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Efficacy of probiotic supplements on Parkinson's disease: A systematic review and meta-analysis

Xiaxia Jin, Wendi Dong, Kaile Chang, Yongmei Yan and Xiaochun Liu

Complementary Therapies in Medicine, 2024, 82, 103045
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The effect of diet on Parkinson’s disease progression, symptoms and severity: a review of randomised controlled trials

Aakash Prasad, Connie Glover, Marshal S. Shuler, Viswas Dayal and Fiona E. Lithander

Proc. Nutr. Soc., 2025, 1
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Microbiome-based therapeutics for Parkinson's disease

Adam M. Hamilton, Ian N. Krout, Alexandria C. White and Timothy R. Sampson

Neurotherapeutics, 2024, 21, e00462
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Short-chain fatty acids mediate enteric and central nervous system homeostasis in Parkinson’s disease: innovative therapies and their translation

Shimin Pang, Zhili Ren, Hui Ding and Piu Chan

Neural Regeneration Research, 2025
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Gut-directed therapy in Parkinson’s disease

Laura Benvenuti, Clelia Di Salvo, Gabriele Bellini, Luisa Seguella, Francesco Rettura, Giuseppe Esposito, Luca Antonioli, Roberto Ceravolo, Nunzia Bernardini, Carolina Pellegrini and Matteo Fornai

Front. Pharmacol., 2024, 15
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The Effect of Gut Microbiota-Targeted Interventions on Neuroinflammation and Motor Function in Parkinson’s Disease Animal Models—A Systematic Review

Paul-Ștefan Panaitescu, Vlad Răzniceanu, Ștefania-Maria Mocrei-Rebrean, Vlad Sever Neculicioiu, Hanna-Maria Dragoș, Carmen Costache and Gabriela Adriana Filip

CIMB, 2024, 46, 3946
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The gut microbiota–brain axis in neurological disorders

Mingming You, Nan Chen, Yuanyuan Yang, Lingjun Cheng, Hongzhang He, Yanhua Cai, Yating Liu, Haiyue Liu and Guolin Hong

MedComm, 2024, 5
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Probiotic: A Gut Microbiota-Based Therapeutic Approaches for the Treatment of Parkinson’s Disease

Monalisa Rout, Shakti Ketan Prusty and Durga Madhab Kar

CRCEP, 2025, 20, 322
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Gut Microbiota-Based Interventions for Parkinson’s Disease: Neuroprotective Mechanisms and Current Perspective

Deepak Kumar, Mahendra Bishnoi, Kanthi Kiran Kondepudi and Shyam Sunder Sharma

Probiotics & Antimicro. Prot., 2025, 17, 2438
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Gut metatranscriptomics based de novo assembly reveals microbial signatures predicting immunotherapy outcomes in non-small cell lung cancer

David Dora, Peter Kiraly, Csenge Somodi, Balazs Ligeti, Edit Dulka, Gabriella Galffy and Zoltan Lohinai