The Potential Effects of Quercetin-Loaded Nanoliposomes on Amoxicillin/Clavulanate-Induced Hepatic Damage: Targeting the SIRT1/Nrf2/NF-κB Signaling Pathway and Microbiota Modulation

Mahran Mohamed Abd El-Emam, Mahmoud Mostafa, Amina A. Farag, Heba S. Youssef, Azza S. El-Demerdash, Heba Bayoumi, Mohammed A. Gebba, Sawsan M. El-Halawani, Abdulrahman M. Saleh, Amira M. Badr and Shorouk El Sayed

Antioxidants, 2023, 12, 1487
DOI: 10.3390/antiox12081487

Integrated metabolomics and intestinal microbiota analysis to reveal anti-post-weaning diarrhea mechanisms of Modified Yupingfeng Granule in Rex rabbits

Dongbo Li, Chao Li, Ning Liu, Hanzhong Liu, Zhiju Yu, Quanjin Liu, Gang Shu, Juchun Lin, Wei Zhang, Guangneng Peng, Ling Zhao, Huaqiao Tang, Haohuan Li, Funeng Xu and Hualin Fu

Front. Microbiol., 2025, 16
DOI: 10.3389/fmicb.2025.1470731

Nontargeted metabolomics combining with intestinal microbiota and hypolipidemia targets elucidates anti-hyperlipidemia effect of Sangju yinzha tea in hyperlipidemia rats

Jinmei Wang, Lin Guo, Xuting Hao, Tianhao Li, Dongqi Liu, Fu Zhang, Xiaoyu Chen and Wenyi Kang

Food Bioscience, 2025, 65, 106012
DOI: 10.1016/j.fbio.2025.106012

Gut Microbiota-Targeted Intervention of Hyperlipidemia Using Monascus-Fermented Ginseng

Qing Zhou, Cuiting Yang, Mingyue Jia, Qingsong Qu, Xinhui Peng, Weishuo Ren, Guoqing Li, Yueyang Xie, Bingxuan Li and Xinyuan Shi

Pharmaceuticals, 2025, 18, 661
DOI: 10.3390/ph18050661

Silymarin prevents endothelial dysfunction by upregulating Erk-5 in oxidized LDL exposed endothelial cells

Rohit Patel, Sanjay Kumar, Johnna F. Varghese, Navneendra Singh, Rana P. Singh and Umesh C.S. Yadav

Microvascular Research, 2024, 153, 104667
DOI: 10.1016/j.mvr.2024.104667

The associations between dietary flavonoid intake and hyperlipidemia: data from the national health and nutrition examination survey 2007–2010 and 2017–2018

Yingying Wan, Dan Ma, Linghua Yu, Wende Tian, Tongxin Wang, Xuanye Chen, Qinghua Shang and Hao Xu

Front. Nutr., 2024, 11
DOI: 10.3389/fnut.2024.1374970

Metabolomics revealed that quercetin improved spleen metabolism disorders and regulated the brain-spleen axis in perimenopausal depression model rats

Ranqi Yao, Wenqi Cui, Weidi Wang, Chenlu Feng, Ying Chen and Xiujuan Zhao

Journal of Pharmaceutical and Biomedical Analysis, 2025, 258, 116744
DOI: 10.1016/j.jpba.2025.116744

The impact of traditional Chinese medicine and dietary compounds on modulating gut microbiota in hepatic fibrosis: A review

Xingting Xue, Hongbing Zhou, Jiaxing Gao, Xinghua Li, Jia Wang, Wanfu Bai, Yingchun Bai, Liya Fan, Hong Chang and Songli Shi

Heliyon, 2024, 10, e38339
DOI: 10.1016/j.heliyon.2024.e38339

Targeting the gut microbiota and lipid metabolism: potential mechanisms of natural products for the treatment of non-alcoholic fatty liver disease

Yutian Zhang, Tianlin Wang, Junquan Han, Jielin Song, Chaoshuai Yang, Lei Liang, Huizhen Li and Hong Wang

Front. Pharmacol., 2025, 16
DOI: 10.3389/fphar.2025.1610498

Short-term microplastic exposure: A double whammy to lung metabolism and fecal microflora in diabetic SD rats

Minghui Li, Guozhu Ye, Yuhang Liu, Tao Yang, Baoshan Zhao, Ru Jiang and Guoyou Chen

Ecotoxicology and Environmental Safety, 2025, 297, 118229
DOI: 10.1016/j.ecoenv.2025.118229

Microbes: Drivers of Chenpi manufacturing, biotransformation, and physiological effects

Yanjiao Fu, Chao Wang, Zhipeng Gao, Yanfang Liao, Mingfang Peng, Fuhua Fu, Gaoyang Li, Donglin Su, Jiajing Guo and Yang Shan

Food Chemistry, 2025, 464, 141631
DOI: 10.1016/j.foodchem.2024.141631

Reduced abundance of Fusobacterium signifies cardiovascular benefits of sodium glucose cotransporter 2 inhibitor in type 2 diabetes: a single arm clinical trial

Shuhui Yang, Jiankun Deng, Xiaoxu Weng, Zhaojie Ma, Nie Lin, Yili Xiao, Rui Zuo, Yufei Hu, Canbin Zheng, Xiaoshan Zeng, Qimao Lin and Kaijian Hou

Front. Pharmacol., 2025, 16
DOI: 10.3389/fphar.2025.1600464

Gut microbiota: a potential new regulator of hypertension

Yanmin Ge, Jiaxin Wang, Lincong Wu and Junduo Wu

Front. Cardiovasc. Med., 2024, 11
DOI: 10.3389/fcvm.2024.1333005

Interactions between traditional chinese medicine and gut microbiota in chronic diseases

Lei Chen, Meijun Liu, Xiaoli Chen, Aiping Lyu, Kenneth Cheung and Yongai Xiong

Pharmacological Research - Modern Chinese Medicine, 2025, 16, 100659
DOI: 10.1016/j.prmcm.2025.100659

Thymus atlanticus Supplementation Attenuates Hepatic Steatosis in High-Fat Diet Fed Guinea Pigs

Hamza Elbouny, Brahim Ouahzizi, Oussama Bekkouch, Amal Bennani, Souliman Amrani, Mhamed Ramchoun, Khalid Sellam and Chakib Alem

Journal of Herbs, Spices & Medicinal Plants, 2024, 30, 26
DOI: 10.1080/10496475.2023.2248908

Research Progress and Prospects of Flavonoids in the Treatment of Hyperlipidemia: A Narrative Review

Xingtong Chen, Jinbiao Yang, Yunyue Zhou, Qiao Wang, Shuang Xue, Yukun Zhang and Wenying Niu

Molecules, 2025, 30, 3103
DOI: 10.3390/molecules30153103

Royal jelly acid alleviates diet-induced hyperlipidemia through regulation of oxidative stress and tryptophan metabolism

Dan-dan Zhi, Xi-ying He, Lin-fu Yang, Yun-fei Xue, Yi-qiu Liu, Dan Yue, Yi-nan Feng, Kun Dong and Ya-kai Tian

European Journal of Pharmacology, 2025, 998, 177500
DOI: 10.1016/j.ejphar.2025.177500

Effects of plant natural products on metabolic-associated fatty liver disease and the underlying mechanisms: a narrative review with a focus on the modulation of the gut microbiota

Tianqi Cai, Xinhua Song, Xiaoxue Xu, Ling Dong, Shufei Liang, Meiling Xin, Yuhong Huang, Linghui Zhu, Tianxing Li, Xueke Wang, Yini Fang, Zhengbao Xu, Chao Wang, Meng Wang, Jingda Li, Yanfei Zheng, Wenlong Sun and Lingru Li

Front. Cell. Infect. Microbiol., 2024, 14
DOI: 10.3389/fcimb.2024.1323261

Untargeted Metabolomics Revealed that Quercetin Inhibited Ferroptosis by Improving Metabolic Disorder in the Hippocampus of Perimenopausal Depression Model Rats

Yali Hou, Heng Qian, Ranqi Yao, Ziran Yu, Jing Wang, Jiaohua Dai, Wenqi Cui, Jian Li and Xiujuan Zhao

Mol Neurobiol, 2025, 62, 2872
DOI: 10.1007/s12035-024-04445-5

Metabolome combined with intestinal flora reveals a novel mechanistic insight into the collaboration of Monascus vinegar polysaccharide and organic acid in regulating lipid metabolism in hyperlipidemia

Jia Song, Yingqi Li, Shangzu Gu, Yu Zheng, Tingting Gao, Jiayi Hou, Bingning Gao, Jianxin Wang and Min Wang

Food Bioscience, 2024, 61, 104807
DOI: 10.1016/j.fbio.2024.104807

Glycosylation of Quercetin by Selected Entomopathogenic Filamentous Fungi and Prediction of Its Products’ Bioactivity

Tomasz Tronina, Mateusz Łużny, Monika Dymarska, Monika Urbaniak, Ewa Kozłowska, Michał Piegza, Łukasz Stępień and Tomasz Janeczko

IJMS, 2023, 24, 11857
DOI: 10.3390/ijms241411857

Revitalizing premature ovarian failure: quercetin counteracts imatinib-induced apoptosis via the PI3K/AKT signaling pathway based on network pharmacology

Min Ji, Shiqi Weng, Xia Li, Qin Xiao, Yan Tong, Yan Zhou, Tao Luo and Zhaoxia Liu

Naunyn-Schmiedeberg's Arch Pharmacol, 2025, 398, 833
DOI: 10.1007/s00210-024-03293-3

Recent research on the bioactivity of polyphenols derived from edible fungi and their potential in chronic disease prevention

Wenbin Yu, Yufei Zhang, Yi Lu, Zhiwei Ouyang, Jiahua Peng, Yayi Tu and Bin He

Journal of Functional Foods, 2025, 124, 106627
DOI: 10.1016/j.jff.2024.106627

A comprehensive study on the underlying mechanisms of the lipid-lowering effects of Bao Li Er Capsule in hyperlipidemia

Xuelan Fu, Jiehong Xing, Chengjun Yuan, Qingling Liu, Jixiao Zhu, Jinxiang Zeng, Haisha Lu, Huiqing Li, Guoyue Zhong and Jian Liang

Journal of Traditional and Complementary Medicine, 2025
DOI: 10.1016/j.jtcme.2025.03.006

Natto alleviates hyperlipidemia in high-fat diet-fed mice by modulating the composition and metabolic function of gut microbiota

Le-Yuan Shang, Shuo Zhang, Min Zhang, Xiao-Dong Sun, Qi Wang, Yu-Jie Liu, Yan-Ni Zhao, Mei Zhao, Peng-Jiao Wang and Xiu-Li Gao

Journal of Functional Foods, 2024, 112, 105968
DOI: 10.1016/j.jff.2023.105968

Combined analysis of cecal microbiota and metabolomics reveals the intervention mechanism of Dayuan Yin in acute lung injury

Lei Zhang, Wei Zhu and Zepeng Zhang

Front. Pharmacol., 2024, 15
DOI: 10.3389/fphar.2024.1436017

Integrated network pharmacology, metabolomics and molecular docking analysis to reveal the mechanisms of quercetin in the treatment of hyperlipidemia

Tao Chen, Tongtong Wang, Yuanxiang Shi, Jun Deng, Xiao Yan, Chenbin Zhang, Xin Yin and Wen Liu

Journal of Pharmaceutical and Biomedical Analysis, 2025, 252, 116507
DOI: 10.1016/j.jpba.2024.116507