Lianhui Sun, Yuan Zhang, Boyu Yang, Sijun Sun, Pengshan Zhang, Zai Luo, Tingting Feng, Zelin Cui, Ting Zhu, Yuming Li, Zhengjun Qiu, Guangjian Fan and Chen Huang

Nat Commun, 2023, 14
DOI: 10.1038/s41467-023-42025-8

Lactate and lactylation: novel perspectives on fibrosis pathogenesis and therapeutic directions

Huanwei Liang, Linlin Xu and Yi Yang

J Transl Med, 2025, 23
DOI: 10.1186/s12967-025-06748-0

Deacetylase Sirtuin 1 mitigates type I IFN- and type II IFN-induced signaling and antiviral immunity

Shuang-Shuang Yu, Rong-Chun Tang, Ao Zhang, Shijin Geng, Hengxiang Yu, Yan Zhang, Xiu-Yuan Sun, Jun Zhang and J.-H. James Ou

J Virol, 2024, 98
DOI: 10.1128/jvi.00088-24

Lactylation‑mediated ferroptosis: A novel mechanism and therapeutic prospects in human diseases (Review)

Zhengjun Lin, Yugang Zou, Songzhu Zou and Kunming Wen

Int J Mol Med, 2025, 57, 1
DOI: 10.3892/ijmm.2025.5713

Lysine lactylation: Regulatory mechanisms, role in health and disease, and its therapeutic potential

Xu Yan, Guangming Zhang, Huayuan Wei, Lin Yang and Xijuan Jiang

Drug Discovery Today, 2025, 30, 104420
DOI: 10.1016/j.drudis.2025.104420

The lactate metabolism and protein lactylation in epilepsy

Xi Kuang, Shuang Chen and Qingmei Ye

Front. Cell. Neurosci., 2025, 18
DOI: 10.3389/fncel.2024.1464169

The role of protein lactylation in brain health and disease: current advances and future directions

Mingrui Han, Wenfeng He, Wengen Zhu and Linjuan Guo

Cell Death Discov., 2025, 11
DOI: 10.1038/s41420-025-02408-w

Identification and Validation of a Novel Lactylation-related Gene Signature to Predict the Prognosis of Endometrial Cancer

Linna Chen, Meng Xia, Weijia Wen, Li Yuan, Yan Jia, Xueyuan Zhao, Haolin Fan, Songlin Liu, Tianyu Liu, Pan Liu, Hongye Jiang, Wei Wang, Yuandong Liao, Chunyu Zhang and Shuzhong Yao

Discov Onc, 2025, 16
DOI: 10.1007/s12672-025-02663-4

Lactylation in cancer progression and drug resistance

Yuxiu Sun, He Wang, Zhe Cui, Tingting Yu, Yuanming Song, Haolai Gao, Ruihong Tang, Xinlei Wang, Binru Li, Wenxin Li and Zhe Wang

Drug Resistance Updates, 2025, 81, 101248
DOI: 10.1016/j.drup.2025.101248

The lactate-lactylation axis in renal fibrosis: potential mechanisms in diabetic kidney disease

Xuejiao Wei, Mengtuan Long, Jiayuan Yu and Yujun Du

Annals of Medicine, 2025, 57
DOI: 10.1080/07853890.2025.2587326

Histone lactylation regulates cancer progression by reshaping the tumor microenvironment

Junxing Qu, Peizhi Li and Zhiheng Sun

Front. Immunol., 2023, 14
DOI: 10.3389/fimmu.2023.1284344

The (patho)physiological roles of the individual deacylase activities of a sirtuin

Weiping Zheng

Chem Biol Drug Des, 2024, 103
DOI: 10.1111/cbdd.14460

Functional analysis of protein post‐translational modifications using genetic codon expansion

Tao Peng, Tandrila Das, Ke Ding and Howard C. Hang

Protein Science, 2023, 32
DOI: 10.1002/pro.4618

Recent advances of lysine lactylation in prokaryotes and eukaryotes

Wenjuan Zhao, Jiayi Xin, Xin Yu, Zhifang Li and Nan Li

Front. Mol. Biosci., 2025, 11
DOI: 10.3389/fmolb.2024.1510975

Pharmacologically targeting protein lactylation to overcome cancer drug resistance

Yumin Wang, Jinxia Chen, Yan Wang, Jun Zhao, Junjing Zhang and Hongquan Wang

European Journal of Medicinal Chemistry, 2025, 296, 117905
DOI: 10.1016/j.ejmech.2025.117905

Research progress of abnormal lactate metabolism and lactate modification in immunotherapy of hepatocellular carcinoma

Yiwei Xu, Xiaodong Hao, Yidan Ren, Qinchen Xu, Xiaoyan Liu, Shuliang Song and Yunshan Wang

Front. Oncol., 2023, 12
DOI: 10.3389/fonc.2022.1063423

A global view of the human post-translational modification landscape

Naoya Kitamura and James J. Galligan

Biochemical Journal, 2023, 480, 1241
DOI: 10.1042/BCJ20220251

Targeting lactate-related cell cycle activities for cancer therapy

Jia Lin, Geng Liu, Lidian Chen, Hang Fai Kwok and Yao Lin

Seminars in Cancer Biology, 2022, 86, 1231
DOI: 10.1016/j.semcancer.2022.10.009

Unlocking the multifaceted molecular functions and diverse disease implications of lactylation

Fengyang Jing, Jianyun Zhang, Heyu Zhang and Tiejun Li

Biological Reviews, 2025, 100, 172
DOI: 10.1111/brv.13135

Genetic code expansion reveals site-specific lactylation in living cells reshapes protein functions

Chang Shao, Shuo Tang, Siqin Yu, Chenguang Liu, Yueyang Zhang, Tianyan Wan, Zimeng He, Qi Yuan, Shihan Wu, Hanqing Zhang, Ning Wan, Mengru Zhan, Ren Xiang Tan, Haiping Hao, Hui Ye and Nanxi Wang

Nat Commun, 2025, 16
DOI: 10.1038/s41467-024-55165-2

Insight into the roles of lactylation in macrophages: functions and clinical implications

Min Shu, Dingci Lu, Ziyi Zhu, Fei Yang and Zhaowu Ma

Clinical Science, 2025, 139, 151
DOI: 10.1042/CS20242737

A multi-dimensional approach to unravel the intricacies of lactylation related signature for prognostic and therapeutic insight in colorectal cancer

Huixia Huang, Keji Chen, Yifei Zhu, Zijuan Hu, Yaxian Wang, Jiayu Chen, Yuxue Li, Dawei Li and Ping Wei

J Transl Med, 2024, 22
DOI: 10.1186/s12967-024-04955-9

Lactylated Apolipoprotein C‐II Induces Immunotherapy Resistance by Promoting Extracellular Lipolysis

Jian Chen, Deping Zhao, Yupeng Wang, Ming Liu, Yuan Zhang, Tingting Feng, Chao Xiao, Huan Song, Rui Miao, Li Xu, Hongwei Chen, Xiaoying Qiu, Yi Xu, Jingxuan Xu, Zelin Cui, Wei Wang, Yanchun Quan, Yifeng Zhu, Chen Huang, Song Guo Zheng, Jian‐yuan Zhao, Ting Zhu, Lianhui Sun and Guangjian Fan

Advanced Science, 2024, 11
DOI: 10.1002/advs.202406333

Lactoylglutathione promotes inflammatory signaling in macrophages through histone lactoylation

Marissa N. Trujillo, Erin Q. Jennings, Emely A. Hoffman, Hao Zhang, Aiden M. Phoebe, Grace E. Mastin, Naoya Kitamura, Julie A. Reisz, Emily Megill, Daniel Kantner, Mariola M. Marcinkiewicz, Shannon M. Twardy, Felicidad Lebario, Eli Chapman, Rebecca L. McCullough, Angelo D'Alessandro, Nathaniel W. Snyder, Darren A. Cusanovich and James J. Galligan

Molecular Metabolism, 2024, 81, 101888
DOI: 10.1016/j.molmet.2024.101888

Lactate and Lactylation in Sepsis: A Comprehensive Review

Sijia Liu, Ting Yang, Qingsong Jiang, Liang Zhang, Xinhui Shi, Xin Liu and Xiaoli Li

JIR, 2024, Volume 17, 4405
DOI: 10.2147/JIR.S459185

Lactylation: novel epigenetic regulatory and therapeutic opportunities

Haoqin Fan, Fan Yang, Zhenghui Xiao, Haiyan Luo, Huaiyang Chen, Zhi Chen, Qiming Liu and Yunbin Xiao

American Journal of Physiology-Endocrinology and Metabolism, 2023, 324, E330
DOI: 10.1152/ajpendo.00159.2022

Lactylation in tumor: mechanisms and therapeutic potentials

Dandan Wang, Hao Rong, Ke Ma and Jun Peng

Front. Immunol., 2025, 16
DOI: 10.3389/fimmu.2025.1609596

Cellular and Biophysical Applications of Genetic Code Expansion

Han Bin Yi, Seungeun Lee, Kyungdeok Seo, Hyeongjo Kim, Minah Kim and Hyun Soo Lee

Chem. Rev., 2024, 124, 7465
DOI: 10.1021/acs.chemrev.4c00112

Genetically Encoded Fluorescent and Bioluminescent Probes for HDAC8

Ying Wang, Lin Sun and Weimin Xuan

ChemBioChem, 2025, 26
DOI: 10.1002/cbic.202500096

Glyoxalase 2 Coordinates de Novo Serine Metabolism

Marissa N. Trujillo, Erin Q. Jennings, Dominique O. Farrera, Naoya Kitamura, Colin C. Anderson, Sarah Gehrke, Julie A. Reisz, Mogens Johannsen, James R. Roede, Angelo D'Alessandro and James J. Galligan

ChemBioChem, 2025, 26
DOI: 10.1002/cbic.202401086

Targeting Lactylation Offers Therapy to Reverse Cell Death Resistance

Yumin Wang, Jinxia Chen, Yan Wang, Yuwei Cao, Yulin Li, Yonglin Zhu, Zhe Zhang, Shuang Wu and Hongquan Wang

DDDT, 2025, Volume 19, 11371
DOI: 10.2147/DDDT.S567488